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The Medicinal and Pharmaceutical Chemistry section publishes pioneering research across all aspects of medicinal chemistry and drug discovery science. It covers a broad range of topics including rational drug design and optimization, target identification and validation, imaging agents, drug delivery and pharmacology of bioactive molecules.Read More
The Medicinal and Pharmaceutical Chemistry section publishes pioneering research across all aspects of medicinal chemistry and drug discovery science. It covers a broad range of topics including rational drug design and optimization, target identification and validation, imaging agents, drug delivery and pharmacology of bioactive molecules. Areas covered include, but are not limited to:
· Design, synthesis and optimization of novel biologically active molecules with significant potential as new pharmacological agents, tools, probes or potential drugs
· Molecular modifications of known chemical entities that lead to a significantly improved understanding of their structure-activity relationships
· Discovery technologies for biologically active molecules from synthetic and natural sources
· Novel and improved methodologies with broad application to medicinal chemistry
· Molecular biological studies of macromolecular targets leading to improved understanding of molecular recognition
· Novel computational, cheminformatics and structural studies for the identification or structure-activity-relationship analysis of bioactive molecules, ligands and their targets
· Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds
· Pharmacogenetic and pharmacogenomic studies used to enhance drug design and bring new drugs to the market
All studies must contribute a mechanistic understanding of the relationship between molecular structure and biological activity or mode of action. All computational studies must demonstrate a clear use in medicinal chemistry through comparison with experimental data. Studies testing new or existing compounds as pharmacological agents must be carried out in the presence of clear positive and negative controls and include a hypothesis-driven compound design rationale. Studies presenting potential antimicrobial agents should report tests for cytotoxicity and activity against non-related pathogens.
Indexed in: PubMed Central, Scopus, Web of Science, Google Scholar, DOAJ, CrossRef, Chemical Abstracts Service (CAS), CLOCKSS
PMCID: all published articles receive a PMCID
Medicinal and Pharmaceutical Chemistry welcomes submissions of the following article types: Correction, Data Report, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Specialty Grand Challenge and Technology and Code.
All manuscripts must be submitted directly to the section Medicinal and Pharmaceutical Chemistry, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
Articles published in the section Medicinal and Pharmaceutical Chemistry will benefit from the Frontiers impact and tiering system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a Frontiers Focused Review - a tier-climbing article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Chemistry.
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