Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Accepted on 15 Aug 2025

Activity Evaluation of Multifunctional H₂S Donors for Anti-Inflammatory, Cardioprotective, and Hepatoprotective Applications

in Medicinal and Pharmaceutical Chemistry

Donghe Wang
Yujie Meng
Yihong Liu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1643663

104 views

Original Research

Published on 11 Aug 2025

Discovery of compound 1105486 as a selective inhibitor of B4GALT1: potential for pancreatic cancer therapy

in Medicinal and Pharmaceutical Chemistry

Xu Yunyun
Mou Yiping

Frontiers in Chemistry

doi 10.3389/fchem.2025.1651402

479 views

Original Research

Published on 08 Aug 2025

Discovery of N′-(1-(coumarin-3-yl)ethylidene)benzenesulfonohydrazide as a novel wound healing enhancer: synthesis, biological assessment, and molecular modeling

in Medicinal and Pharmaceutical Chemistry

Eman F. Khaleel
Heba Abdelmegeed
Abdel-Razik H. Abdel-Razik
Manal S. Ebaid
Ninh The Son
Nguyen Xuan Ha
Hoda Atef Abdelsattar Ibrahim
Mohamed A. Abdelrahman
Abdelsamed I. Elshamy
Jarosław Dziadek

Frontiers in Chemistry

doi 10.3389/fchem.2025.1621717

565 views

Original Research

Accepted on 07 Aug 2025

Natural Product Erianin: Mitigating FOLFOX Toxicity and Enhancing Against Colorectal cancer

in Medicinal and Pharmaceutical Chemistry

Fuqin Yang
Zeqiao Li
Haishan Zhang
Mingxiao Zhang
Zhenwei He
Xiaoqin Zheng
Yingru Zhu
Pei Long
Ruirui Ding
Zhengbin Lin

Frontiers in Chemistry

doi 10.3389/fchem.2025.1650197

227 views

Original Research

Published on 01 Aug 2025

Citrus aurantifolia essential oil: antiaging potential through integrated in vitro and in silico studies

in Medicinal and Pharmaceutical Chemistry

Yasmin A. Elkhawas
Mahmoud A. El Hassab
Omkulthom Al kamaly
Ahmed T. Negmeldin
Taghreed A. Majrashi
Wagdy M. Eldehna
Nada M. Mostafa

Frontiers in Chemistry

doi 10.3389/fchem.2025.1577871

911 views

Original Research

Published on 31 Jul 2025

Design and synthesis of 3,4-seco-Lupane triterpene derivatives: targeting tumor angiogenesis and inducing apoptosis in triple-negative breast cancer

in Medicinal and Pharmaceutical Chemistry

Chunyu Gao
Hongbo Teng
Wenxin Zhang
Yaru Zhao
Chunguo Cui
Zerbo Patrice
Liyan Wang
Yan Zhao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630939

657 views

Review

Accepted on 30 Jul 2025

Comprehensive Medicinal Chemistry Survey Highlights A Portfolio of Lead Molecules for Alzheimer's Disease Therapy

in Medicinal and Pharmaceutical Chemistry

Pravin R Bhansali
Brian Muntean
Shashank M Sonkusare
Shubhangi S Savale
Yasanandana S. Wijayasinghe
Douglas C Sloan
Ganesh U Chaturbhuj

Frontiers in Chemistry

doi 10.3389/fchem.2025.1642190

287 views

Opinion

Accepted on 29 Jul 2025

Are Basic and Lipophilic Chain Groups Highly Required in Leishmanicidal Quinolines to Favor the Phagolysosome Accumulation?

in Medicinal and Pharmaceutical Chemistry

Angel Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1655979

198 views

Original Research

Accepted on 28 Jul 2025

Preclinical evaluation of 6-Gingerol in modulating gut microbiota and SCFAs to mitigate Clostridium difficile-associated diarrhea in mice

in Medicinal and Pharmaceutical Chemistry

Fu-Zhi Ma
Lin Zhu
Meng Li
Xiao-Hong Yu
Ze-Wei Tang
Cong-En Zhang
Zhijie Ma

Frontiers in Chemistry

doi 10.3389/fchem.2025.1635781

194 views

Original Research

Published on 28 Jul 2025

In silico design of novel dihydropteridone derivatives with oxadiazoles as potent inhibitors of MCF-7 breast cancer cells

in Medicinal and Pharmaceutical Chemistry

Mourad Aloui
Mohamed El fadili
Mohammed Er-rajy
Somdutt Mujwar
Hatem A. Abuelizz
Sara Er-rahmani
Elhalaoui Menana

Frontiers in Chemistry

doi 10.3389/fchem.2025.1590593

939 views

Original Research

Published on 28 Jul 2025

Computational advances in the design and discovery of artemis inhibitors for radiosensitization in cancer therapy

in Medicinal and Pharmaceutical Chemistry

Maryam Bashir
Usman Abdullah
Sadia Nazir
Farhan Siddique
Nasir Jalal

Frontiers in Chemistry

doi 10.3389/fchem.2025.1597454

1,054 views

Mini Review

Published on 25 Jul 2025

Application of nano and microformulations to improve the leishmanicidal response of quinoline compounds: a brief review

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero
Karina N. Gonzalez
Marcos A. Sabino

Frontiers in Chemistry

doi 10.3389/fchem.2025.1622566

1,002 views

Review

Published on 23 Jul 2025

Research progress on the chemical composition of galli gigeriae endothelium corneum

in Medicinal and Pharmaceutical Chemistry

Guo-Lian Gan
Hongxin Zhou
Zhen-Bin Lin
Xiang Li
Jing-Jin Lin
Li Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1644192

1,041 views

Original Research

Published on 21 Jul 2025

Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome

in Medicinal and Pharmaceutical Chemistry

Xinxin Mao
Shuqing Shi
Chunmei Chen
Yumeng Li
Bingxuan Zhang
Qingqiao Song

Frontiers in Chemistry

doi 10.3389/fchem.2025.1617676

1,278 views

Original Research

Published on 18 Jul 2025

MicroRNA-31 mediated inhibition of keratin 6 by PSORI-CM01: a novel approach to psoriasis amelioration

in Medicinal and Pharmaceutical Chemistry

Shilei Wang
Jingkai Wang
Helin Pan
Ruogu Yang
Fanli Zeng
Yongfei Fang
Jinwei Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636529

876 views

Original Research

Published on 17 Jul 2025

Evaluation of newly synthesized schiff base Pd(II) complexes for prostate cancer treatment through in vitro cytotoxicity and molecular mechanistic studies

in Medicinal and Pharmaceutical Chemistry

Damnjan Pantic
Nikola Mirkovic
Tatjana Vulovic
Danijela Jovanovic
Stefan Jakovljevic
Petar Canovic
Milan Zaric
Radica Zivkovic Zaric
Marina Kostic
Jovana Dragojevic

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636477

1,275 views