Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Accepted on 09 Jun 2025

A Novel Thiazole-Sulfonamide Hybrid Molecule as a promising Dual Tubulin/Carbonic Anhydrase IX Inhibitor with Anticancer Activity

in Medicinal and Pharmaceutical Chemistry

Hussam Elddin Nabeih Khasawneh
Elryah I. Ali
Ranya Mohammed Elmagzoub
Raed Fanoukh Aboqader Al-Aouadi
Wesam Taher Almagharbeh
Ghallab Alotaibi
Stefan Bräse
Abdullah Alkhammash

Frontiers in Chemistry

doi 10.3389/fchem.2025.1606848

111 views

Original Research

Published on 09 Jun 2025

HIF1A acts as target of XiHuang Pill in the treatment of papillary thyroid cancer by regulating dedifferentiation

in Medicinal and Pharmaceutical Chemistry

Xu-Zhe Yu
Wei-Li Zhu
Hua-Chun Qian
Chun-Jiang Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1607067

231 views

Correction

Published on 09 Jun 2025

Correction: Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

in Medicinal and Pharmaceutical Chemistry

Yongzhi He
Jiachun Lu
Yushan Luo
Rizhao Pang
Xiaoming Hu
Lijuan Ding
Hua Xiao
Yunyun Wang
Wenchun Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1636136

182 views

Original Research

Published on 09 Jun 2025

Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective TIM-3 inhibitor for NSCLC immunotherapy

in Medicinal and Pharmaceutical Chemistry

Xinxin Ying
Yangyong Lou
Yueming Wu
Weiwei Hu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1622511

275 views

Original Research

Accepted on 03 Jun 2025

Seasonal Changes in Aloysia oblanceolata Moldenke Essential Oil

in Medicinal and Pharmaceutical Chemistry

Paulo Vinicius Lima Santos
Mateus Machado Lima
Flavia Cristina A. Lucas
JOYCE KELLY R. DA SILVA
Jose Guilherme Soares Maia
Pablo Luis Baia Figueiredo

Frontiers in Chemistry

doi 10.3389/fchem.2025.1564404

117 views

Mini Review

Published on 30 May 2025

Current developments of metal- and metalloid-based quinoline compounds as leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Edgar Del Carpio
Lino Hernández
Vito Lubes
Francisco Jourdan
Hugo Cerecetto
Gonzalo Scalese
Dinorah Gambino
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1586044

808 views
1 citation

Mini Review

Published on 30 May 2025

A comprehensive revision on the use of quinoline antimalarial drugs as leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Romina E. Avanzo
Guadalupe García Liñares
Noris Rodríguez
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1608340

660 views
1 citation

Original Research

Published on 30 May 2025

Neuraminidase as a novel therapeutic management strategy for Alzheimer’s disease: evidenced through molecular docking, molecular dynamic simulation and gene expression analysis

in Medicinal and Pharmaceutical Chemistry

Sami I. Alzarea
Omar Awad Alsaidan
Hassan H. Alhassan
Abdulaziz Ibrahim Alzarea
Tariq G. Alsahli
Metab Alharbi
Muhammad Afzal
Mohammad Jaffar Sadiq Mantargi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1574702

680 views

Original Research

Published on 30 May 2025

Black ginseng under forest as a natural antidepressant: insights into its active components and mechanisms

in Medicinal and Pharmaceutical Chemistry

Yixuan Sui
Yiying Tan
Yajing Li
Xiaochen Gao
Han Lu
Jiaming Shen
Xuesheng Hu
Lei Wang
Liting Zhao
Jiaming Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1619060

538 views

Original Research

Accepted on 29 May 2025

Ruta montana L. from Morocco: Comprehensive Phytochemical Analysis and Exploration of its Antioxidant, Antimicrobial, Antiinflammatory and Analgesic Properties

in Medicinal and Pharmaceutical Chemistry

Mohamed El Ouardi
Drioiche Aziz
Imane Tagnaout
Aicha Benouahi
Omkulthom Al Kamaly
Abdelaaty Abdelaziz Shahat Hussein
El Makhoukhi Fadoua
Handaq Nadia
Sevser Sahpaz
Touriya Zair

Frontiers in Chemistry

doi 10.3389/fchem.2025.1614984

122 views

Original Research

Accepted on 27 May 2025

Metabolomics, Antioxidant, and Enzyme Inhibitory Effects of Citrus aurantium Fruits

in Medicinal and Pharmaceutical Chemistry

Omayma Eldahshan
Salwa Bouabdallah
Rawan Abd El-khalek
Mahmoud El Hassab
Gokhan Zengin
Ahmed T Negmeldin
Eman Khaleel
Wagdy Mohamed Eldehna
Nada Mostafa

Frontiers in Chemistry

doi 10.3389/fchem.2025.1613827

353 views

Original Research

Accepted on 27 May 2025

Two-Dimensional QSAR-Driven Virtual Screening for Potential Therapeutics against Trypanosoma cruzi

in Medicinal and Pharmaceutical Chemistry

Naseer Maliyakkal
SUNIL KUMAR
Ratul Bhowmik
Harish Chandra Vishwakarma
Prabha Yadav
Bijo Mathew

Frontiers in Chemistry

doi 10.3389/fchem.2025.1600945

234 views

Original Research

Published on 27 May 2025

Network pharmacology and molecular dynamics simulation reveal antineoplastic potential of Antarctic sponge-derived suberitenones

in Medicinal and Pharmaceutical Chemistry

Prasenjit Bhowmik
Rahul Mallick
Asim K. Duttaroy

Frontiers in Chemistry

doi 10.3389/fchem.2025.1545834

953 views

Original Research

Published on 21 May 2025

Synthesis and characterization of thymol-derived phenoxy acetamide derivatives using DFT, molecular docking, and parasitological investigations

in Medicinal and Pharmaceutical Chemistry

Ahmed R. Rabee
Saied M. Soliman
Hamida Abdel-Hamid
Esraa A. Moneer
Sara H. Akl
Yahya H. Shahin
Aliaa A. Masoud
Doaa Ahmad Ghareeb
Mariusz Jaremko
Abdul-Hamid Emwas

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579923

9,455 views

Original Research

Accepted on 20 May 2025

Phomaderide, a Unique (6/5/4/5/6) Spiro-Cyclic Dimmer from the Desert Plant Endophytic Fungus Phoma betae A. B. Frank (Didymellaceae)

in Medicinal and Pharmaceutical Chemistry

Haodi Sun
Yan-Duo Wang
Hui-Qi Fang
Jian Yang
Yutong Hua
Gang Ding
Lanping Guo

Frontiers in Chemistry

doi 10.3389/fchem.2025.1583666

205 views

Original Research

Published on 19 May 2025

Engineering of antimicrobial peptide Brevinin-1pl: arginine, lysine, and histidine substitutions enhance antimicrobial-anticancer efficacy with reduced cytotoxicity

in Medicinal and Pharmaceutical Chemistry

Jingkai Wang
Fanli Zeng
Xiaoling Chen
Tao Wang
Lei Wang
Mei Zhou
Yangyang Jiang
Tianbao Chen
Yongfei Fang
Jinwei Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1579097

1,202 views