Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Review

Accepted on 20 Oct 2025

Exploring Tetrazole Chemistry: Synthetic Techniques, Structure-Activity Relationship, and Pharmacological Insights in Antimicrobial and Anticancer Therapy

in Medicinal and Pharmaceutical Chemistry

Lalmohan Maji
Ghanshyam Teli
Rohit Pal
Neelesh Maheshwari
Praveen Kumar Soni
Gurubasavaraja Swamy Purawarga Matada
Mahendra Singh Rathore
Venkatesan Saravanan
Kathiravan Muthukumaradoss

Frontiers in Chemistry

doi 10.3389/fchem.2025.1700143

Original Research

Published on 10 Oct 2025

Antibacterial effects of coniferyl alcohol-derived dehydrogenation polymer on chlamydial infection in vitro

in Medicinal and Pharmaceutical Chemistry

Anna Pfundner
Tamara Weinmayer
Nora Geissler
Ana Kovacevic
Dragica Spasojevic
Ksenija Radotic
Marijana Stojanovic
Irma Schabussova
Ursula Wiedermann
Aleksandra Inic-Kanada

Frontiers in Chemistry

doi 10.3389/fchem.2025.1654478

1,189 views

Correction

Published on 09 Oct 2025

Correction: Membrane-targeting antibacterial isoniazid schiff base against S. aureus and biofilms

in Medicinal and Pharmaceutical Chemistry

Yaguang Liu
Lianzhi Hu
Binbin Liu
Zheng Qu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1706525

539 views

Original Research

Published on 09 Oct 2025

Elucidating multifaceted targets of Marein in cerebral ischemia-reperfusion injury

in Medicinal and Pharmaceutical Chemistry

Weidan Luo
Jian Wang
Ying Fan
Meng Yuan
Wanying Xie
Yang Su
Xingchun Wang
Yi Zhong
Yibo Zhang
Jiaxin Zhan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1651873

1,633 views

Original Research

Accepted on 07 Oct 2025

Elucidating the Phytochemical Profile of Sophorae Flavescentis Radix-Astragali Radix Herb Pair: An Integrated LC-QTOF-MS/MS, Pharmacological Activity, and Network Pharmacology Study on Anti-Hepatocellular Carcinoma Effects

in Medicinal and Pharmaceutical Chemistry

Yidi Yin
Jiameng Qu
Lanzhuo Qu
Zhiyuan Li
Huarong Xu
Qing Li

Frontiers in Chemistry

doi 10.3389/fchem.2025.1687098

279 views

Review

Published on 02 Oct 2025

Targeting RNA-binding proteins with small molecules: perspectives and challenges

in Medicinal and Pharmaceutical Chemistry

Olivier Mpungi Konde
Williams Balela Balela
Tania Bishola Tshitenge

Frontiers in Chemistry

doi 10.3389/fchem.2025.1649692

1,711 views

Mini Review

Published on 01 Oct 2025

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine

in Medicinal and Pharmaceutical Chemistry

Yuanyuan Wu
Hui Huang
Xianglong Zhao
Junhao Lin
Jialiang Guo
Zhengjin Jiang
Kesara Ar-Sanork
Tao Deng
Dongsheng Xu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1694998

1,935 views

Review

Published on 01 Oct 2025

Comprehensive medicinal chemistry survey highlights a portfolio of lead molecules for Alzheimer’s disease therapy

in Medicinal and Pharmaceutical Chemistry

Pravin R. Bhansali
Shashank M. Sonkusare
Shubhangi S. Savale
Yasanandana S. Wijayasinghe
Yini Liao
Douglas C. Sloan
Ganesh U. Chaturbhuj
Brian S. Muntean

Frontiers in Chemistry

doi 10.3389/fchem.2025.1642190

3,009 views

Original Research

Published on 24 Sep 2025

Polybrominated diphenyl ether profiles in adipose tissues of breast cancer patients and their carcinogenic potential investigation based on network toxicology and molecular docking

in Medicinal and Pharmaceutical Chemistry

Qihao Zhao
Xi Liu
Haoyi Chen
Yingming Jin
Qian Chen
Yiteng Huang
Lin Peng

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630283

2,302 views

Original Research

Published on 22 Sep 2025

Reversed phase HPLC analysis of mobocertinib and its impurities and studies on the structure and biological activity of a new degradation product

in Medicinal and Pharmaceutical Chemistry

Ronghua Ni
Jisu Qin
Wenyi Wu
Jinqiu Xu
Qunfeng Luo
Liangliang Cai

Frontiers in Chemistry

doi 10.3389/fchem.2025.1659507

2,718 views

Original Research

Published on 16 Sep 2025

Design, synthesis, antiproliferative assessments, and computational studies of new quinolin-2(1H)-ones as dual EGFR/HER-2 inhibitors

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Hesham A. Abou-Zied
Martin Nieger
Stefan Bräse
Bahaa G. M. Youssif
Hendawy Tawfik

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638489

2,319 views

Mini Review

Published on 15 Sep 2025

Quinolines: the role of substitution site in antileishmanial activity

in Medicinal and Pharmaceutical Chemistry

Orlando G. Elso
Guadalupe García Liñares

Frontiers in Chemistry

doi 10.3389/fchem.2025.1645334

3,327 views

Original Research

Published on 11 Sep 2025

Manganese-doped nanotheranostic system for MRI-guided photothermal therapy of malignant pleural mesothelioma: in vivo study

in Medicinal and Pharmaceutical Chemistry

Lichang Lei
Hongjiao Zi
ShaoLei Kang
Hui Duan
Zhenghua Zhang
Chao Gao
Ruoyun Xu
Dan Han

Frontiers in Chemistry

doi 10.3389/fchem.2025.1659283

2,037 views

Original Research

Accepted on 09 Sep 2025

Development and Validation of a Robust Stability-Indicating Reversed Phase High Performance Liquid Chromatography (RP-HPLC) Method for Simultaneous Quantification of Brimonidine Tartrate and Timolol Maleate (Combigan®) in Bulk and Pharmaceutical Dosage Forms

in Medicinal and Pharmaceutical Chemistry

Aktham Mestareehi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1678541

839 views

Editorial

Published on 09 Sep 2025

Editorial: Quinoline as lead structures for the development of leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero
Gustavo Benaim

Frontiers in Chemistry

doi 10.3389/fchem.2025.1694616

1,506 views

Original Research

Published on 09 Sep 2025

Membrane-targeting antibacterial isoniazid schiff base against S. aureus and biofilms

in Medicinal and Pharmaceutical Chemistry

Yaguang Liu
Lianzhi Hu
Binbin Liu
Zheng Qu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1654358

1,697 views