Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 24 Sep 2025

Polybrominated diphenyl ether profiles in adipose tissues of breast cancer patients and their carcinogenic potential investigation based on network toxicology and molecular docking

in Medicinal and Pharmaceutical Chemistry

Qihao Zhao
Xi Liu
Haoyi Chen
Yingming Jin
Qian Chen
Yiteng Huang
Lin Peng

Frontiers in Chemistry

doi 10.3389/fchem.2025.1630283

1,244 views

Original Research

Published on 22 Sep 2025

Reversed phase HPLC analysis of mobocertinib and its impurities and studies on the structure and biological activity of a new degradation product

in Medicinal and Pharmaceutical Chemistry

Ronghua Ni
Jisu Qin
Wenyi Wu
Jinqiu Xu
Qunfeng Luo
Liangliang Cai

Frontiers in Chemistry

doi 10.3389/fchem.2025.1659507

2,024 views

Mini Review

Accepted on 19 Sep 2025

Recent Progress in the Application of Hydrophilic Interaction Liquid Chromatography for the Separation and Analysis of Traditional Chinese Medicine

in Medicinal and Pharmaceutical Chemistry

源源吴
Hui Huang
Xianglong Zhao
Junhao Lin
Jialiang Guo
Zhengjin Jiang
Kesara Ar- Sanork
Tao Deng
Dongsheng Xu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1694998

925 views

Original Research

Published on 16 Sep 2025

Design, synthesis, antiproliferative assessments, and computational studies of new quinolin-2(1H)-ones as dual EGFR/HER-2 inhibitors

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Hesham A. Abou-Zied
Martin Nieger
Stefan Bräse
Bahaa G. M. Youssif
Hendawy Tawfik

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638489

1,504 views

Mini Review

Published on 15 Sep 2025

Quinolines: the role of substitution site in antileishmanial activity

in Medicinal and Pharmaceutical Chemistry

Orlando G. Elso
Guadalupe García Liñares

Frontiers in Chemistry

doi 10.3389/fchem.2025.1645334

2,655 views

Original Research

Published on 11 Sep 2025

Manganese-doped nanotheranostic system for MRI-guided photothermal therapy of malignant pleural mesothelioma: in vivo study

in Medicinal and Pharmaceutical Chemistry

Lichang Lei
Hongjiao Zi
ShaoLei Kang
Hui Duan
Zhenghua Zhang
Chao Gao
Ruoyun Xu
Dan Han

Frontiers in Chemistry

doi 10.3389/fchem.2025.1659283

1,506 views

Original Research

Accepted on 10 Sep 2025

Elucidating Multifaceted targets of Marein in Cerebral Ischemia-Reperfusion Injury

in Medicinal and Pharmaceutical Chemistry

XINGXIA WANG
Jian Wang
Ying Fan
Meng Yuan
Wanying Xie
Yi Zhong
Xinyao Huang
Yibo Zhang
Yang Su
Xuan Mao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1651873

842 views

Original Research

Accepted on 09 Sep 2025

Development and Validation of a Robust Stability-Indicating Reversed Phase High Performance Liquid Chromatography (RP-HPLC) Method for Simultaneous Quantification of Brimonidine Tartrate and Timolol Maleate (Combigan®) in Bulk and Pharmaceutical Dosage Forms

in Medicinal and Pharmaceutical Chemistry

Aktham Mestareehi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1678541

770 views

Editorial

Published on 09 Sep 2025

Editorial: Quinoline as lead structures for the development of leishmanicidal agents

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero
Gustavo Benaim

Frontiers in Chemistry

doi 10.3389/fchem.2025.1694616

1,377 views

Original Research

Published on 09 Sep 2025

Membrane-targeting antibacterial isoniazid schiff base against S. aureus and biofilms

in Medicinal and Pharmaceutical Chemistry

Yaguang Liu
Lianzhi Hu
Binbin Liu
Zheng Qu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1654358

1,417 views

Original Research

Published on 05 Sep 2025

Activity evaluation of multifunctional H2S donors for anti-inflammatory, cardioprotective, and hepatoprotective applications

in Medicinal and Pharmaceutical Chemistry

Donghe Wang
Yujie Meng
Yihong Liu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1643663

1,262 views

Original Research

Published on 05 Sep 2025

Design, synthesis, and biological assessment of a novel series of coumarin-tethered thiazole derivatives as potential antibacterial agents

in Medicinal and Pharmaceutical Chemistry

Manal S. Ebaid
Hanaa Farag
Mohamed Abdelraof
Abdulrahman M. Saleh
Mohamed G. Thabit
Jarosław Dziadek
Ahmed A. Youssef
Ahmed Sabt

Frontiers in Chemistry

doi 10.3389/fchem.2025.1627186

1,916 views

Original Research

Published on 04 Sep 2025

Nutraceutical potential of moroccan Juglans regia: phytochemical profiling and multi-modal evaluation of bioactivities

in Medicinal and Pharmaceutical Chemistry

Aziz Drioiche
Omkulthom Al kamaly
Soukayna Baammi
Khalid Zibouh
Rachid Amaiach
Laila Bennani
El Ouali Lalami Abdelhakim
Ahde El Imache
Fadoua EL Makhoukhi
Sevser Sahpaz

Frontiers in Chemistry

doi 10.3389/fchem.2025.1638205

1,522 views

Original Research

Published on 03 Sep 2025

UHPLC-HRMS analysis combined with feature-based molecular networking methods for systematic identification of chemicals in AnShenDingZhiLing and its absorbed metabolites

in Medicinal and Pharmaceutical Chemistry

Tai Han
Deqing Ni
Wanqing Zhu
Dan Fang
An Kang
Yumiao Wu
Jichao Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1647159

1,419 views

Review

Accepted on 02 Sep 2025

Targeting RNA-binding proteins with small molecules: perspectives and challenges

in Medicinal and Pharmaceutical Chemistry

Olivier Mpungi Konde
Williams Balela Balela
Tania Bishola Tshitenge

Frontiers in Chemistry

doi 10.3389/fchem.2025.1649692

473 views

Editorial

Published on 01 Sep 2025

Editorial: Medicinal chemistry for neglected tropical diseases using in-vitro, in-vivo and in silico approaches

in Medicinal and Pharmaceutical Chemistry

Suraj N. Mali
Essa M. Saied
Cleydson Breno Rodrigues dos Santos
Jorddy Neves Cruz

Frontiers in Chemistry

doi 10.3389/fchem.2025.1689034

1,180 views