About this Research Topic
Although the field of cardiovascular diseases (CVD) witnessed tremendous progress in the context of
discoveries and treatment in the last three decades, CVD remain today the leading cause of death
worldwide with preventive therapy being the most promising approach. The effective interventional
and pharmacological methods in improving both diagnosis and prognosis are usually counteracted
with complications that are shifting the field of treatment from therapeutic to supportive.
Complications are mainly due to the presence of comorbidities and the absence of clear knowledge
on the basics of disease development. Inflammation constitutes a hallmark in CVD development and
immunomodulatory approaches are gaining significant interest in managing multiple CVD diseases
including myocardial infarction, heart failure, hypertension, pericarditis, and atherosclerosis.
The main objective of this special issue is to focus on the most promising immunomodulatory
approaches whether in the context of pharmacological intervention or in boosting our basic
understanding and knowledge by identifying novel targets and mechanisms. All studies pertaining to
specific cytokine or chemokine treatment, immune cell adoptive transfers, immune cell or cytokine
knockout models, targeted immunosupression, and immune cell/cytokine/chemokine
spatiotemporal distribution in the context of myocardial infarction, hypertension, atherosclerosis
and heart failure are welcome in this issue. Specials reviews highlighting the most promising findings
in this field are welcomed.
Potential topics include but are not limited to the following:
Immune therapy (suppression or activation) in preventing or limiting heart failure
development following acute (i.e MI, pericarditis) or chronic (i.e. hypertension, DCM) insult.
Immune therapy (suppression/activation/engineered) in the context of established models
of hypertension, MI, atherosclerosis, heart failure and pericarditis
Models of immune cell knock out (global/targeted) in the context of established models of
hypertension, MI, atherosclerosis, heart failure and pericarditis.
Immune target identification in the context of hypertension, MI, atherosclerosis, heart
failure and pericarditis
Immune cell/cytokine/chemokine spatiotemporal distribution in the context of established
models of hypertension, MI, atherosclerosis, heart failure and pericarditis
Coronary heart disease and other vascular diseases, for example, failed vein grafts and AV
Vasculitis and/or the impact of COVID-19 in cardiovascular medicine
All types of manuscripts are considered, including original basic science reports, translational
research, clinical studies, review articles, and methodology papers.
Keywords: Cardiovascular Diseases, Cardiovascular Immunomodulation, Cardiovascular Inflammation, Myocardial Infarction, Atherosclerosis, Heart Failure, Hypertension, Pericarditis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.