About this Research Topic
Salmonella is one of the communicable zoonotic bacteria which can infect poultry, rodents, mammals and humans. Infection of Salmonella can cause gastroenteritis and typhoid fever in the host. Annually, there are 1.3 billion cases of Salmonella gastroenteritis, which leads to approximately 3 million deaths worldwide. Understanding the molecular mechanisms allowing Salmonella to invade and persist in the hosts is crucial to better fight this pathogen.
The survival and persistent infection of Salmonella is mainly dependent on its ability to resist against the host immune response. During the battle between the pathogen and host cells, the host has evolved various defense system to inhibit the survival of the pathogen in cells, or resist against its invasion. Meanwhile, Salmonella has developed many methods to break through the host defense system to survive in host cells. It has gained various pathways to evade the innate and adaptive immune responses of the host. During the infection process, Salmonella needs to adapt to the environment change in vivo, such as bile salts, antimicrobial peptides, acidic pH, and metabolites. How Salmonella senses these molecules and transfers the signal into the pathogen and coordinately regulates the expression of virulence factors remains to be studied further.
Salmonella can express many effectors to inhibit the inflammatory response and evade the innate immune response. Many effectors have been identified yet, such as SteE, AvrA and SpiC, however new effectors remain to be investigated. We also lack the knowledge of how these effectors regulate the immune response to escape the clearance by host cells. On the other side, it is also important to understand how host cells respond to the Salmonella infection by mediating the innate immunity and the adaptive immunity. By now, the phenomenon of Salmonella persistent infection has been frequently observed, but the molecular mechanisms of Salmonella and its host interaction needs to be further investigated.
This Research Topic aims to collect Original Research articles and Reviews about Salmonella-host interactions, including themes about Salmonella virulence factors, host immune responses during Salmonella infection and the molecular mechanisms for Salmonella’s immune evasion and persistent infection.
- Regulation of the expression of virulence factors by Salmonella according to the environmental changes encountered throughout the infection process;
- Identification of the yet unknown effector proteins of Type III secretion system and their mechanisms of secretion;
- Molecular mechanisms of Salmonella-host interaction including inflammatory pathway, autophagy, and pyrolysis;
- Salmonella evasion of host immunity, including innate immunity and adaptive immunity.
Keywords: Salmonella, Virulence factor, Persistent infection, Immune evasion, Anti-bacterial immunity
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