Systemic diseases may share common risk factors that lead to an increased oral inflammatory response when there is disruption in microbial homeostasis. The host response to oral bacteria may be altered by systemic conditions such as diabetes, rheumatoid arthritis, atherosclerotic disease, cardiovascular diseases, obesity, oncologic diseases, and cognitive impairment disorders such as Alzheimer's disease. Recent studies have provided insights into the emergence and persistence of dysbiotic oral microbial communities, which can mediate inflammatory chronic diseases both locally and systemically. One of the key factors in sustained inflammation and tissue destruction is the active bacterial subversion of the host immune response allowing pathogen persistence in the inflammatory environment of the oral mucosa. Pathogenic mechanisms of immune subversion seem to contribute to complications at systemic sites and for some conditions such as diabetes this is a two-way relationship whereas poor control of the systemic condition also leads to complications in oral health.
The aim of this Research Topic is to gather reliable evidence and mechanistic insights about oral microbiota dissemination from their oral environment to distant sites. Ultimately, the goal is to compile the latest evidence demonstrating how the disruption of immune homeostasis promotes or accelerates chronic inflammatory processes.
In order to expand the existing knowledge in the field, Original Research articles and Reviews focusing on the following sub-themes are of special interest:
- The interaction of oral bacteria and the host immune system in systemic conditions;
- Description of new oral bacterial species, their features and analytic tools for analyses in a disease related context;
- New associations between oral bacteria and systemic diseases or new insights and critical analysis about already existing literature;
- Mechanistic insights regarding the role of oral bacteria as inflammation-triggers and their potential role for systemic disease pathogenesis.
Purely descriptive studies without hypotheses will not be considered within this Research Topic.
Systemic diseases may share common risk factors that lead to an increased oral inflammatory response when there is disruption in microbial homeostasis. The host response to oral bacteria may be altered by systemic conditions such as diabetes, rheumatoid arthritis, atherosclerotic disease, cardiovascular diseases, obesity, oncologic diseases, and cognitive impairment disorders such as Alzheimer's disease. Recent studies have provided insights into the emergence and persistence of dysbiotic oral microbial communities, which can mediate inflammatory chronic diseases both locally and systemically. One of the key factors in sustained inflammation and tissue destruction is the active bacterial subversion of the host immune response allowing pathogen persistence in the inflammatory environment of the oral mucosa. Pathogenic mechanisms of immune subversion seem to contribute to complications at systemic sites and for some conditions such as diabetes this is a two-way relationship whereas poor control of the systemic condition also leads to complications in oral health.
The aim of this Research Topic is to gather reliable evidence and mechanistic insights about oral microbiota dissemination from their oral environment to distant sites. Ultimately, the goal is to compile the latest evidence demonstrating how the disruption of immune homeostasis promotes or accelerates chronic inflammatory processes.
In order to expand the existing knowledge in the field, Original Research articles and Reviews focusing on the following sub-themes are of special interest:
- The interaction of oral bacteria and the host immune system in systemic conditions;
- Description of new oral bacterial species, their features and analytic tools for analyses in a disease related context;
- New associations between oral bacteria and systemic diseases or new insights and critical analysis about already existing literature;
- Mechanistic insights regarding the role of oral bacteria as inflammation-triggers and their potential role for systemic disease pathogenesis.
Purely descriptive studies without hypotheses will not be considered within this Research Topic.
