About this Research Topic
Recently, the effects of environmental factors, diseases and food safety on the oocyte quality and maternal control are paid more attention. It is shown that the environmental exposure like air, soil, water and biota chemical pollutants, the diseases like obesity and diabetes, or contaminated foods intake like mycotoxins all could affect oocyte maturation quality, reduce the fertilization and early embryo development competence. These exposure could disrupt the meiosis resumption, cell cycle progression, the meiotic spindle organization, chromosome segregation, actin dynamics, organelle function and polar body extrusion. These exposed oocytes showed mitochondria dysfunction, DNA damage, oxidative stress, apoptosis/autophagy and reduced fertilization rate, indicating that the oocyte quality is affected. Although several solutions like melatonin and Resveratrol are proposed to protect the oocytes from toxic exposure through their effects on oxidative stress by the anti-oxidant functions, the effective solution and application are still need more studies.
This Research Topic aimed to focus on the molecular regulation and the toxic exposure on mammalian oocyte maturation. The expanding understanding about the molecular mechanism of oocyte quality control will provide exciting new insights into the oocyte maturation and early development.
We welcome the submission of Original Research Articles and Reviews that cover, but not limited to the following topics:
• Cell cycle control of oocytes
• Cytoskeleton dynamics of oocytes
• Organelle function of oocytes
• Environmental toxicity and disease on oocyte quality
• The potential solutions for reduced oocyte quality
Keywords: oocyte, cell cycle, spindle, cytokinesis, actin
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