About this Research Topic
Bioactive lipid products of lipid metabolism play active roles in regulating cellular functions. These bioactive lipid mediators, including fatty acids and their metabolic products, acylglycerol derivatives, endocannabinoids, lysophospholipids, sphingolipids, cholesterol metabolites, etc., have numerous functions important for homeostatic regulation of energy metabolism, the cardiovascular system, strength, behavior etc. However, they can also contribute to pathologies such as insulin resistance, inflammation, obesity, type 1 and type 2 diabetes, fatty liver disease, cardiovascular diseases, etc.
The production of the numerous bioactive mediators involves metabolic networks. Eicosanoids as products of fatty acids, including prostaglandins, thromboxanes, leukotrienes, lipoxins hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids, and others, have drawn great attention because of their vital roles in many physiological and pathophysiological processes. Endocannabinoids, lysophospholipids, sphingolipids, acylglycerol derivatives and cholesterol metabolites also possess important biofunctions. The functions of a great number of bioactive lipids are still not clear. Moreover, even the same lipid mediator can reveal different functions by activating different receptors, thus the necessity to clarify the receptors and signal transduction of these lipids. Targeting these lipids or their metabolic enzymes may provide potential therapeutic strategies for metabolic disorders and related diseases.
This Research Topic will accept original articles or reviews that address the following:
• Based on lipidomics, elucidate the change of bioactive lipid metabolism under conditions of metabolic diseases and the underlying mechanisms.
• Elucidate the effects of the bioactive lipids on cell behavior and tissue micro-environment.
• Explore the molecular mechanism of the bioactive lipids participating energy in homeostasis and related disorders; identify receptors and explore the signal transduction of the bioactive lipids.
• The role of the bioactive lipids in the crosstalk among metabolic tissues.
• Explore the potential of bioactive lipids or their metabolic enzymes as therapeutic targets of energy metabolic disorders and related diseases, such as obesity, insulin resistance, type 1 and type 2 diabetes, fatty liver disease, cardiovascular diseases, etc.
Topic Editor Dr. Jun Yang is a part-time employee of EicOsis LLC (Davis, California, USA). All other Topic Editors declare no competing interests with regards to the Research Topic subject.
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