Research Topic

The Role of Bioactive Lipids in Homeostasis and Pathology

About this Research Topic

Bioactive lipid products of lipid metabolism play active roles in regulating cellular functions. These bioactive lipid mediators, including fatty acids and their metabolic products, acylglycerol derivatives, endocannabinoids, lysophospholipids, sphingolipids, cholesterol metabolites, etc., have numerous ...

Bioactive lipid products of lipid metabolism play active roles in regulating cellular functions. These bioactive lipid mediators, including fatty acids and their metabolic products, acylglycerol derivatives, endocannabinoids, lysophospholipids, sphingolipids, cholesterol metabolites, etc., have numerous functions important for homeostatic regulation of energy metabolism, the cardiovascular system, strength, behavior etc. However, they can also contribute to pathologies such as insulin resistance, inflammation, obesity, type 1 and type 2 diabetes, fatty liver disease, cardiovascular diseases, etc.

The production of the numerous bioactive mediators involves metabolic networks. Eicosanoids as products of fatty acids, including prostaglandins, thromboxanes, leukotrienes, lipoxins hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids, and others, have drawn great attention because of their vital roles in many physiological and pathophysiological processes. Endocannabinoids, lysophospholipids, sphingolipids, acylglycerol derivatives and cholesterol metabolites also possess important biofunctions. The functions of a great number of bioactive lipids are still not clear. Moreover, even the same lipid mediator can reveal different functions by activating different receptors, thus the necessity to clarify the receptors and signal transduction of these lipids. Targeting these lipids or their metabolic enzymes may provide potential therapeutic strategies for metabolic disorders and related diseases.

This Research Topic will accept original articles or reviews that address the following:
• Based on lipidomics, elucidate the change of bioactive lipid metabolism under conditions of metabolic diseases and the underlying mechanisms.
• Elucidate the effects of the bioactive lipids on cell behavior and tissue micro-environment.
• Explore the molecular mechanism of the bioactive lipids participating energy in homeostasis and related disorders; identify receptors and explore the signal transduction of the bioactive lipids.
• The role of the bioactive lipids in the crosstalk among metabolic tissues.
• Explore the potential of bioactive lipids or their metabolic enzymes as therapeutic targets of energy metabolic disorders and related diseases, such as obesity, insulin resistance, type 1 and type 2 diabetes, fatty liver disease, cardiovascular diseases, etc.

Topic Editor Dr. Jun Yang is a part-time employee of EicOsis LLC (Davis, California, USA). All other Topic Editors declare no competing interests with regards to the Research Topic subject.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

15 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

15 March 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..