Research Topic

Methods on the Assessment of Human Baroreflex Function

About this Research Topic

The baroreflex constitutes one of the crucial elements of neural control exerted by the autonomic nervous system (ANS) over the cardiovascular system The assessment of cardio-vagal and sympathetic baroreflex function has been introduced to evaluate ANS function and status, and to predict cardiovascular risk in heart failure, diabetes, hypertension, and patients in intensive care units. This includes pharmacological and non-pharmacological baroreflex testing, time and frequency analysis of blood pressure, heart rate variability, neural sympathetic activity, and modeling.

Engineers have developed many tools that have been slowly adapted by clinicians. The variety and complexity of methods is large. Some methods and software are propriety and has been used as a black box. Open methods, standards, and software applications are needed to promote collaboration and understanding between experts in signal processing, neuroscience, and clinical science.

Although there have been various approaches proposed for the estimation of baroreflex function, there is still no standard approach for assessment.

This Research Topic will provide a basic review of human autonomic control of blood pressure, common clinical procedures, mathematical and programmatic methods. This includes time and frequency domain analysis of cardiovagal and sympathetic baroreflex. Novel approaches for human baroreflex assessment and its applications in clinical data will be presented.

This article collection is targeting mathematicians, engineers, and research scientists and should have a basic common sense for understanding for each group. Contributions addressing the physiology, applied algorithms, and programming for each manuscript should stimulate interactions between writers and readers. We encourage the authors to submit methodical papers with open source code (Python, Octave/Matlab, C/Qt), and data sets that can be used and tested by readers.

We welcome authors to address, but not limited to, the following topics:

1. Basic reviews on blood pressure human autonomic control, from the autonomic baroreflex testing perspective.
2. Common autonomic cardio-vagal baroreflex function tests and methods:
a) Pharmacological baroreflex testing: Modified Oxford methods, autonomic blockade
b) Non-pharmacological interventional baroreflex testing: Breathing maneuvers, Valsalva, neck suction, tilt table tests, lower body negative pressure, etc.
c) Spontaneous baroreflex testing in time and frequency domain
Time domain: spontaneous sequence technique, SD, RMSSD, geometric, Poincaré plot, etc.
Frequency domain: heart rate and blood pressure variability, transfer function analysis, etc.
d) Novel algorithms for the estimation of baroreflex sensitivity

3. Specialized methods for sympathetic baroreflex with microneurography
4. Mathematical modeling and new concepts
5. Novel clinical applications and outcomes
6. Advancements in experimental design for the estimation of baroreflex function.


Keywords: Human Barorefelx Function, Mathematical Modeling, Programmatic Methods, time and frequency domain analysis, autonomic baroreflex testing


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The baroreflex constitutes one of the crucial elements of neural control exerted by the autonomic nervous system (ANS) over the cardiovascular system The assessment of cardio-vagal and sympathetic baroreflex function has been introduced to evaluate ANS function and status, and to predict cardiovascular risk in heart failure, diabetes, hypertension, and patients in intensive care units. This includes pharmacological and non-pharmacological baroreflex testing, time and frequency analysis of blood pressure, heart rate variability, neural sympathetic activity, and modeling.

Engineers have developed many tools that have been slowly adapted by clinicians. The variety and complexity of methods is large. Some methods and software are propriety and has been used as a black box. Open methods, standards, and software applications are needed to promote collaboration and understanding between experts in signal processing, neuroscience, and clinical science.

Although there have been various approaches proposed for the estimation of baroreflex function, there is still no standard approach for assessment.

This Research Topic will provide a basic review of human autonomic control of blood pressure, common clinical procedures, mathematical and programmatic methods. This includes time and frequency domain analysis of cardiovagal and sympathetic baroreflex. Novel approaches for human baroreflex assessment and its applications in clinical data will be presented.

This article collection is targeting mathematicians, engineers, and research scientists and should have a basic common sense for understanding for each group. Contributions addressing the physiology, applied algorithms, and programming for each manuscript should stimulate interactions between writers and readers. We encourage the authors to submit methodical papers with open source code (Python, Octave/Matlab, C/Qt), and data sets that can be used and tested by readers.

We welcome authors to address, but not limited to, the following topics:

1. Basic reviews on blood pressure human autonomic control, from the autonomic baroreflex testing perspective.
2. Common autonomic cardio-vagal baroreflex function tests and methods:
a) Pharmacological baroreflex testing: Modified Oxford methods, autonomic blockade
b) Non-pharmacological interventional baroreflex testing: Breathing maneuvers, Valsalva, neck suction, tilt table tests, lower body negative pressure, etc.
c) Spontaneous baroreflex testing in time and frequency domain
Time domain: spontaneous sequence technique, SD, RMSSD, geometric, Poincaré plot, etc.
Frequency domain: heart rate and blood pressure variability, transfer function analysis, etc.
d) Novel algorithms for the estimation of baroreflex sensitivity

3. Specialized methods for sympathetic baroreflex with microneurography
4. Mathematical modeling and new concepts
5. Novel clinical applications and outcomes
6. Advancements in experimental design for the estimation of baroreflex function.


Keywords: Human Barorefelx Function, Mathematical Modeling, Programmatic Methods, time and frequency domain analysis, autonomic baroreflex testing


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

18 October 2020 Abstract
19 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

18 October 2020 Abstract
19 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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