Research Topic

Invasive Treatments for Obsessive Compulsive Disorder

About this Research Topic

Obsessive compulsive disorder (OCD) is a debilitating psychiatric disease that affects 1-2% of the population. Approximately 10% of patients with OCD are refractory to pharmacologic and psychotherapeutic treatments. Over the past several decades, numerous studies have demonstrated successful use of invasive ...

Obsessive compulsive disorder (OCD) is a debilitating psychiatric disease that affects 1-2% of the population. Approximately 10% of patients with OCD are refractory to pharmacologic and psychotherapeutic treatments. Over the past several decades, numerous studies have demonstrated successful use of invasive lesioning and stimulation procedures to treat these refractory cases. With the advent of deep brain stimulation (DBS) as well as newer, safer, and more precise neurotechnologies for monitoring and altering brain activity, a resurgence of interest in the surgical interventions for OCD and other psychiatric illnesses has arisen.

Armed with new technologies and greater public and scientific interest, scientists are now challenged with the great task of learning more about the pathophysiology of OCD and how to effectively wield these novel methods to improve diagnosis, treatment, and management of patients.

The goal of this Research Topic is to create a platform for discussing the current state of the art in the use of interventional procedure based neurotechnologies in OCD patients, including but not limited to the use of deep brain stimulation, lesioning methods, and other invasive/interventional techniques for the purpose of advancing the treatment or management of patients with refractory OCD.

This Research Topic will chart the current state of knowledge and understanding in the use of invasive treatments for OCD with the hope of guiding future research to focus on gaps in current knowledge. We welcome a diverse array of papers on this topic including empirical research studies, review papers, case series or cohort studies, theoretical contributions, technical reports, and opinion pieces.

Some specific topics of interest:
• Who is a good candidate for surgical management of OCD?
• What promising biomarkers of treatment response or target engagement exist?
• What strategies exist for DBS device programming, titration and optimization?
• What evidence supports such strategies?
• How does one troubleshoot device management for non-responders or partial responders?
• What are the long-term outcomes for patients in terms of quality of life or functional status?
• What evidence exists to determine whether a lesioning or stimulation approach is preferable?
• Evidence related to the timeline of treatment response.
• Analysis of long-term device adjustments and efficacy of DBS for OCD.
• New surgical techniques and targets.
• Neuroimaging, neurophysiology, or circuit-based theories.
• How to choose between DBS or lesioning approaches?


Keywords: OCD, Obsessive Compulsive Disorder, neurotechnologies, deep brain stimulation, Invasive Treatments, surgical interventions


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

14 December 2020 Manuscript
29 January 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

14 December 2020 Manuscript
29 January 2021 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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