About this Research Topic
Faithful genome duplication through DNA replication is pivotal for genome maintenance. A variety of stresses could challenge this fundamental process and therefore endanger the genome integrity and change the cell fate. These stresses include misincorporation of ribonucleotides, unusual DNA structures, common fragile sites, replication-transcription conflicts, oncogene activation, treatment of pharmacological drugs and so forth. Replication stress, if not dealt timely and properly, may result in replication fork collapse, DNA double-strand breaks and genome instability. Moreover, mutations in replication machinery or factors that combat replication stress can lead to numerous diseases such as developmental defects, microcephaly, anemia, aging and cancer. Despite intensive studies, how cells deal with replication stress remains poorly understood. Thus, it is of importance to obtain mechanistic insights in DNA replication process and how DNA replication stresses manipulate and determine the cell fate.
This Research Topic welcomes Original Research articles, Review articles, Mini Review articles and Brief Research Report articles that focus on but are not limited to the following topics:
• Researches that study the consequences of replication stress such as genome instability, apoptosis, senescence, aging and so forth
• DNA modifications or protein post-translational modifications in response to replication stress
• Mechanisms for removal of replication blocks such as DNA inter-strand crosslinks, DNA-protein crosslinks, physical barriers, hard-to-replication regions, R loops and so forth
• Identification and characterization of new components in DNA replication machinery or in combat with replication stress
• Investigation of fundamental DNA replication processes, and mechanism of replication fork recovery and restart
• Technical advance in the field of DNA replication and replication stress
• Researches of replication stress in disease background, including translational or clinical studies of pharmacological drugs that manipulate DNA replication stress
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.