Systemic Regulation of Organ Homeostasis and Implications of Hormones and Immunity

Tissue specific micromilieu has fundamental influence on the physiological functions of cells. The cells have the capacity to differentiate and organize into specialized tissues and organs. Any imbalance in the endocrine/cellular/ligand signaling results in local / systemic malfunctioning of the tissues leading to the diseases. This normally involves more than one system/signaling pathways. Although several studies have furnished sufficient information on various signaling pathways involved in the classical functions of every organ/tissue system. Both autonomous and / or non-autonomous signaling are inter-linked with each other and our knowledge on the potential underlying mechanisms of interaction of two physiological systems like Hormones and Immunity remains elusive.
Hence, it is very essential to understand these two systems in normal and pathological setting which is important for understanding the disease biology and to identify potential interventions for the management of various metabolic / endocrine disorders including cancer.

This Research Topic is aimed to discuss and unravel the idiopathic interactions of Hormones and soluble mediator of immunity with emphasis on general organ development/function in normal and disease conditions. Main focus of this research topic is to understand the cross talk(s) between endocrine systems (hormones and signaling pathways) with innate and adaptive immunity.

In this Research Topic, we welcome the submission of Original Research and Review articles / opinion/ evidence based perspective that include, but not limited, to the following sub-topics/areas

• Signaling and endocrine aspects of the organ function in normal and specific disorder/disease
• Classical and Non-classical functions of Sex-Steroids (Estrogens and Androgens)
• Positive and Negative Feedback system of HPG and HPA axis
• Steroids, GH and Glucocorticoids in energy management and Oxidative stress
• Steroids and other hormones/signaling pathways in Bone Physiology and Immune Protection etc
• Tissue Microenvironment, transcriptional and epigenetic mechanisms that regulate cellular, tissue and Organ Homeostasis
• Non-classical functions of immune cells, in regulating tissue and Organ function (Including Tissue remodeling, wound healing etc)
• Hormonal regulation of immune homeostasis, Self-Tolerance -Autoimmunity (3/4th of the Patients are female)
• Systemic regulation and transport of Hormones and immune cells
• Impact of hormonal dysregulation on cancer progression
• Essential role of hormones in sex differentiation and development of gonads during pre-natal period

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.