About this Research Topic
Metabolites are an important cue to analyze the status of a cell, in a specific environment or genetic alternation, along with other omics data. Particularly metabolism profiling using metabolomics is a useful measurement to track carbon metabolism in various biological systems. Currently, the development of various applications using mass spectrometry allows us to profile targeted/untargeted metabolomes, which provide crucial targets to further the development of a biological system that generates therapeutic or bioactive products. In particular, metabolomics with specific nutrient sources provide data about metabolic flux change, such as flux balance analysis and 13C-labeled flux analysis. The latter approach with 13C-isotopes has been implicated to measure flux distribution of central carbon metabolism which provides major precursors for amino acid biosynthesis and nucleotides.
This Research Topic aims to provide recent developments and knowledge about metabolic profiling in regards to (1) breakthroughs on technical/methodological difficulties on flux analysis, (2) novel applications to identify targets for further development of bioproduct producers,(3) new insights by combining other omics data including flux balance analysis.
This Research Topic also aims to provide recent approaches with metabolic tracing using stable isotopes for (1) the target identification of bioactive compounds for further development, (2) the measurement of flux distribution of bioproduct producers (e.g. amino acid).
This topic seeks to understand metabolic remodeling/re-structuring during certain conditions that are biologically, therapeutically, and industrially significant, and also provide insights for further development.
This Research Topic welcomes Original Research, Review and Methods papers using metabolome or metabolic flux analysis in diverse sectors including, but not limited to:
· Development/improvement of biological systems (any type of cells) for the production of bioactive materials such as amino acids, peptides, and nucleotides.
· Identification of novel metabolic pathways involved in the synthesis of bioactive natural products including antibacterials and anticancer compounds.
· Analysis of biological systems (any type of cells) to discover metabolic remodeling during important biological events including drug treatment and over-production of certain bioproducts.
· Development /optimization of methodologies for metabolomics and metabolic flux analysis.
Dr. Lee holds patents related to Metabolomics and Metabolic Flux Analysis. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Keywords: Metabolomics, metabolic flux analysis, metabolic shift, isotope flux analysis, flux balance analysis, metabolic adaptation, metabolic modelling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.