About this Research Topic
The small ubiquitin-like modifier (SUMO) has emerged as an important regulator of biological processes including the immune response. SUMO can interact with the target proteins in a covalent and non-covalent manner. Furthermore, a cross-talk between SUMO and other post-translational modifications can also occur. SUMO modulates several proteins involved in innate or intrinsic immunity. Direct modification of pathogen proteins or modulation of host proteins involved in innate or intrinsic immunity in response to a pathogen infection have also been found. However, whether pathogens alter the cross-talk between SUMO and other post-translational modifications or how this cross-talk affect to the host-pathogen interplay are still open questions. Different studies have addressed the role of SUMO on specific viral proteins or on proteins playing key role in defense against pathogens. However, more work is necessary to understand the impact of the synergistic role of SUMO on several proteins in the host-pathogen relationship.
The editors’ goal is to compile a collection of manuscripts to provide a comprehensive overview of the current knowledge on the role of SUMO in host-pathogen interaction and the predominant questions for future research.
The aim of the current research topic is to cover recent advances in the involvement of SUMO in innate and intrinsic immunity. Areas covered in this research topic include, but are not limited to:
• SUMO regulation of host proteins involved in intrinsic and innate immunity.
• Novel tools to study the SUMOylation pathway in the context of the immune response.
• Molecular modeling and simulations of SUMO or the SUMOylation system in host-pathogen relationship.
• Interaction of pathogen proteins with SUMO.
• Modulation of the host SUMOylation system by pathogens
• Cross-talk of SUMO with other PTMs in the context of immunity.
Keywords: SUMO, pathogen, immunity, signaling, post translational modification
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.