About this Research Topic
Arterial hypertension and cancer are two of the most important causes of mortality in the world; correlations between these two clinical entities are complex and various. Cancer therapy using old (e.g., mitotic spindle poisons) as well as new (e.g. monoclonal antibody) drugs may cause arterial hypertension through different mechanisms; sometimes the increase of blood pressure levels may be responsible for chemotherapy withdrawal. Among newer cancer therapies, drugs interacting with the VEGF (vascular endothelial growth factors) pathways are the most frequently involved in hypertension development. However, many retrospective studies have suggested a relationship between antihypertensive treatment and the risk of cancer, raising vast public concern.
The purposes of this Research Topic is to evaluate the role of chemotherapy in the pathogenesis of hypertension, to evaluate the general rules of arterial hypertension management in this field and finally to evaluate the effects of antihypertensive therapy on cancer disease.
Human, animal and in vitro models are welcome. Original Research Articles and Reviews focused on but not restricted to the following areas are encouraged:
• Clinical, cellular and molecular interaction between cancer therapy and arterial hypertension (e.g. cancer and neurological disorders)
• Lifestyle (e.g. stress, diet and exercise) role in arterial hypertension related to cancer therapy
• Cardiovascular events in patients undergoing treatment with cancer drugs (such as Anti VEGF, carfilzomib etc)
• Cardiovascular risk stratification in patient with
• Relationship between antihypertensive treatment and risk of cancer
Keywords: Arterial Hypertension, Cancer, VEGF inhibitors, vascular toxicity, heart toxicity
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