Research Topic

Cerebrovascular imaging — from micro- to macroscopic scales

About this Research Topic

Over the past few decades, there have been significant advances in imaging technologies for the evaluation of the neurovascular system. Multiple imaging modalities, such as MRI, CT, PET, optical and ultrasound (US) imaging, as well as photoacoustic imaging, are now available to assess brain vasculature from micro- to macroscopic scales. This is translating into a better understanding of the detailed structural organization of capillaries (<10um), arterioles/venules (~100um), large vessels (mm) including lumen, vessel wall and perivascular space. The function of the cerebrovasculature across different scales can be assessed by imaging vessel wall inflammation, blood flow, blood volume and oxygenation as well as permeability of the blood-brain barrier (BBB). All these progresses should deepen our understanding of the pathophysiologic mechanisms of neurovascular diseases, such as stroke, atherosclerosis, aneurysm, cerebral small vessel disease (cSVD) and vascular cognitive impairment and dementia (VCID), leading to improved clinical management.

In this research topic, we aim to gather recent research advances in technological development and applications of multiscale cerebrovascular imaging methods from micro- to macroscopic scales to promote the understanding of the brain’s neurovascular system and its aberrations in various neurologic diseases. We also aim to encourage the exchange of ideas across researchers with different backgrounds (e.g. imaging scientist, biologist, pathologist, neurologists, psychiatrist, neurosurgeons and radiologists).

We welcome submissions of Original Research, Reviews, Mini-Reviews, Methods and Brief Research Reports on the following topics (but not limited to):
1. Imaging and quantifying structural organization and morphology of capillaries (<10um), arterioles/venules (~100um), and large vessels (mm), including lumen, vessel wall and perivascular space.
2. Assessing the function of the cerebrovasculature by imaging vessel wall inflammation, blood flow, perfusion, blood volume and oxygenation, permeability of the blood-brain barrier (BBB), etc.
3. Multi-scale and/or multi-modal imaging for comprehensive characterization of the cerebrovasculature.
4. Advanced imaging processing methods, computational simulation methods and artificial intelligence for the evaluation of neurovascular function and hemodynamics.
Understanding of the pathophysiologic mechanisms of neurovascular diseases, such as stroke, atherosclerosis, aneurysm, cerebral small vessel disease (cSVD) and vascular cognitive impairment and dementia (VCID).
5. Understanding of the pathophysiologic mechanisms of neurovascular diseases, such as stroke, atherosclerosis, aneurysm, cerebral small vessel disease (cSVD) and vascular cognitive impairment and dementia (VCID).


Keywords: Stroke, vascular cognitive impairment and dementia, MRI, optical imaging; ultrasound imaging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Over the past few decades, there have been significant advances in imaging technologies for the evaluation of the neurovascular system. Multiple imaging modalities, such as MRI, CT, PET, optical and ultrasound (US) imaging, as well as photoacoustic imaging, are now available to assess brain vasculature from micro- to macroscopic scales. This is translating into a better understanding of the detailed structural organization of capillaries (<10um), arterioles/venules (~100um), large vessels (mm) including lumen, vessel wall and perivascular space. The function of the cerebrovasculature across different scales can be assessed by imaging vessel wall inflammation, blood flow, blood volume and oxygenation as well as permeability of the blood-brain barrier (BBB). All these progresses should deepen our understanding of the pathophysiologic mechanisms of neurovascular diseases, such as stroke, atherosclerosis, aneurysm, cerebral small vessel disease (cSVD) and vascular cognitive impairment and dementia (VCID), leading to improved clinical management.

In this research topic, we aim to gather recent research advances in technological development and applications of multiscale cerebrovascular imaging methods from micro- to macroscopic scales to promote the understanding of the brain’s neurovascular system and its aberrations in various neurologic diseases. We also aim to encourage the exchange of ideas across researchers with different backgrounds (e.g. imaging scientist, biologist, pathologist, neurologists, psychiatrist, neurosurgeons and radiologists).

We welcome submissions of Original Research, Reviews, Mini-Reviews, Methods and Brief Research Reports on the following topics (but not limited to):
1. Imaging and quantifying structural organization and morphology of capillaries (<10um), arterioles/venules (~100um), and large vessels (mm), including lumen, vessel wall and perivascular space.
2. Assessing the function of the cerebrovasculature by imaging vessel wall inflammation, blood flow, perfusion, blood volume and oxygenation, permeability of the blood-brain barrier (BBB), etc.
3. Multi-scale and/or multi-modal imaging for comprehensive characterization of the cerebrovasculature.
4. Advanced imaging processing methods, computational simulation methods and artificial intelligence for the evaluation of neurovascular function and hemodynamics.
Understanding of the pathophysiologic mechanisms of neurovascular diseases, such as stroke, atherosclerosis, aneurysm, cerebral small vessel disease (cSVD) and vascular cognitive impairment and dementia (VCID).
5. Understanding of the pathophysiologic mechanisms of neurovascular diseases, such as stroke, atherosclerosis, aneurysm, cerebral small vessel disease (cSVD) and vascular cognitive impairment and dementia (VCID).


Keywords: Stroke, vascular cognitive impairment and dementia, MRI, optical imaging; ultrasound imaging


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 October 2020 Abstract
30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 October 2020 Abstract
30 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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