Reproductive diseases of ruminants, caused by a range of infectious drivers including venereal disease, uterine infection and mastitis, seriously affect the animals’ welfare, and cause huge economic losses to the breeding industry. Immune response is highly relevant in the occurrence and development of reproductive diseases. Many reproductive diseases can be caused by infection due to pathogenic microorganisms, including viruses, bacteria and fungi. These pathogenic microorganisms interact with host cells to activate TLRs, which ultimately trigger the innate or acquired immune responses. Many biomolecules and natural extracts have been identified to treat ruminant diseases by regulating the immune response of the body. Emerging evidence indicates that noncoding RNAs, exosomes and intestinal microorganisms also mediate various immune responses. It is also of clinical importance to identify novel biomarkers for disease diagnosis, prevention and treatment through multi-omics analysis.
Understanding the specific role of innate and acquired immune responses in the occurrence and development of reproductive diseases holds potential for new strategies to prevent and treat reproductive diseases in ruminants.
This Research Topic invites Reviews and Original articles to further understand the regulatory molecular mechanisms of innate and acquired immune responses in the development of ruminant reproductive diseases (excluding mammary disorders), and their application in the disease prevention and treatment.
The scope of the Research Topic includes, but is not limited to, the following themes:
- The underlying mechanisms and application of biomacromolecules and natural extracts in the prevention and treatment of reproductive diseases.
- The relationship between intestinal flora disorders and reproductive diseases.
- The underlying mechanisms and application of exosomes or noncoding RNAs in early diagnosis of reproductive diseases.
- Identification and validation of novel biomarkers for the diagnosis, prevention and treatment of reproductive diseases.
Note: mammary disorders are not in scope for this Research Topic.
Reproductive diseases of ruminants, caused by a range of infectious drivers including venereal disease, uterine infection and mastitis, seriously affect the animals’ welfare, and cause huge economic losses to the breeding industry. Immune response is highly relevant in the occurrence and development of reproductive diseases. Many reproductive diseases can be caused by infection due to pathogenic microorganisms, including viruses, bacteria and fungi. These pathogenic microorganisms interact with host cells to activate TLRs, which ultimately trigger the innate or acquired immune responses. Many biomolecules and natural extracts have been identified to treat ruminant diseases by regulating the immune response of the body. Emerging evidence indicates that noncoding RNAs, exosomes and intestinal microorganisms also mediate various immune responses. It is also of clinical importance to identify novel biomarkers for disease diagnosis, prevention and treatment through multi-omics analysis.
Understanding the specific role of innate and acquired immune responses in the occurrence and development of reproductive diseases holds potential for new strategies to prevent and treat reproductive diseases in ruminants.
This Research Topic invites Reviews and Original articles to further understand the regulatory molecular mechanisms of innate and acquired immune responses in the development of ruminant reproductive diseases (excluding mammary disorders), and their application in the disease prevention and treatment.
The scope of the Research Topic includes, but is not limited to, the following themes:
- The underlying mechanisms and application of biomacromolecules and natural extracts in the prevention and treatment of reproductive diseases.
- The relationship between intestinal flora disorders and reproductive diseases.
- The underlying mechanisms and application of exosomes or noncoding RNAs in early diagnosis of reproductive diseases.
- Identification and validation of novel biomarkers for the diagnosis, prevention and treatment of reproductive diseases.
Note: mammary disorders are not in scope for this Research Topic.
