About this Research Topic
Accumulated evidence shows that microbes (bacteria, fungi, viruses, and archaea) are widely distributed among agriculture animals, and symbiotic microbes have been found in the skin, respiratory system, gastrointestinal tract, reproductive system of agriculture animals. Studies on single microbe treatment (in vivo, explant, in vitro studies) or correlation/causality analysis have indicated the indispensable role of microbes in host health and in various local or systemic dysfunction and diseases. The interaction between microbes and agriculture animals is mainly reflected by the contact between microbes and host epithelial or immune cells which triggers immune and stress responses. Secondary metabolites produced by microbes also play an indirect role in host health.
The development of omics technology has greatly increased the understanding of the interaction between microbes and agriculture animals. Omics analysis can be applied to analyzing hundreds and thousands of variables, such as genes and proteins, through large-scale parallel detection in a short period of time, and to screening out the most obvious differences when combining with bioinformatics analysis. For example, high-throughput sequencing-based on 16S rDNA gene or metagenomic sequencing has identified almost all microbial composition in feces and other complex samples. Transcriptomics, proteomics and metabonomics can identify all gene, protein and small-molecule metabolite sets and their differences under different conditions. Culturomics can set a variety of culture conditions at a time, greatly expanding the number of culturable microbes.
In this Research Topic, we aim to explore the mechanisms of the interaction between microbes and agricultural animals, especially the roles of microbes in animal health and diseases, using single omics or multi-omics analysis combined with other molecular biology technologies. Besides, this Research Topic will focus on the regulation of microbiota and its application in promoting agricultural animal health.
We welcome Brief Research Report, Data Report, Mini Review, Opinion, Original Research and Review on the following aspects of the interaction between microbe and agricultural animals applying single omics or multi-omics analysis
- Single omics or multi-omics analysis of host response to the microbe.
- The change pattern and difference of symbiotic microbiota in disease or different physiological conditions.
- The regulation of microbiota (environmental factors, nutrition, drug, etc.) and its application in promoting agricultural animal health.
Keywords: Interaction Between Microbe and Host, Omics Analysis, Disease, Health, Regulation
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