Harnessing Oncolytic Virus-mediated Antitumor Immunity

106.5K

views

34

authors

13

articles

Editors

2

Philippe Fournier

German Cancer Research Center (DKFZ)

Volker Schirrmacher

German Cancer Research Center (DKFZ)

Impact

About

Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
Keywords: oncolytic virus, cancer immunotherapy, tumor antigen, cancer vaccine, therapy strategies

Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
Keywords: oncolytic virus, cancer immunotherapy, tumor antigen, cancer vaccine, therapy strategies

Download ebook

Share

Editors

Philippe Fournier

German Cancer Research Center (DKFZ)

Volker Schirrmacher

German Cancer Research Center (DKFZ)

Impact

106,481 Total views

76,458 Article views

24,620 Article downloads

5,403 Topic views

Published In

Journal Thumbnail

Frontiers in Oncology

Cancer Immunity and Immunotherapy

Journal Thumbnail

Frontiers in Immunology

Cancer Immunity and Immunotherapy

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic