About this Research Topic
Recent years have seen a remarkable rise in the average age of the population, making caring for the elderly a growing challenge. A better understanding of the underlying mechanisms of aging will be essential to improving the health of elderly. While some elderly people age healthily, most of the elderly will still encounter functional limitations, which we call frailty. Clinically, frailty is a loss of functional homeostasis resulting in a pathophysiological state characterized by the accumulation of molecular, cellular, and tissue damage in different organ systems. When function has already been lost due to injury or illness, frailty can compound the loss and lead to disability.
The immune system is one of the ideal models that can be used for aging studies. The lymphocytes pool includes all populations at different stages of development, differentiation, function and exhaustion, which are regenerative and can be drawn repeatedly for cellular aging studies, such as DNA damage repair, genomic destabilization, epigenetic regulation alteration, telomere shortening, metabolism changes, and abnormal protein folding et al. during the ageing process. Furthermore, the altered B and T lymphocytes function, including the shrinking of B and T lymphocyte receptor repertoire and naïve B and T lymphocyte cells, makes the elderly more susceptible to infectious diseases and leads to poorer prognosis. The B and T lymphocytes, as the major force to monitor the stability of the internal environment of the body, are responsible for the cleanup of senescent and mutated cells. However, the roles of the adaptive immune system and the change of B and T lymphocytes in the negative prospect of aging, such as frailty, are still poorly understood.
To deepen the understanding of the aging immune system, we welcome novel studies exploring B and T lymphocytes in health, aging and frailty along with cellular and molecular mechanisms. Omics and Artificial Intelligence analysis is a new type of research method and applying these methods to health, ageing and frailty research will improve the research efficiency. Secondly, it is equally important to understand the role of the B and T lymphocytes in age related diseases, for example immunological roles in cognitive impairment and neurodegenerative disease. In addition, anti-aging interventions, such as sports, herbal medicine and nutritional therapy has been shown to have a therapeutic effect in prevention and treatment of age-related chronic conditions and frailty. To elucidating the mechanisms of anti-aging interventions could reveal the link between the immune system in anti-ageing and debilitation.
We welcome authors to submit Original Research, Reviews, Mini Reviews, and Clinical Trial articles covering, but not limited to, the following sub-topics:
• The roles of B and T lymphocytes in health, aging and frailty
• Cellular and molecular biomarkers of health, aging and frailty
• Omics and Artificial Intelligence analysis of lymphocytes in health, aging and frailty
• The metabolism change and its mechanisms of B and T lymphocytes in aging and frailty
• Microbiota study and translation application in aging and frailty
• The roles of B and T lymphocytes in cognitive impairment and neurodegenerative disease
• Anti-aging and frailty specific interventions based on antibody and T lymphocytes
Keywords: B lymphocytes, T lymphocytes, aging, frailty, biomarker, artificial intelligence analysis, microbiota studies, neurodegenerative disease, anti-aging interventions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.