About this Research Topic
Commensal and pathogenic Enterobacteriaceae are major colonizers of the animal gut microbiota and pathogenic bacteria cause enteric and extra-intestinal diseases. These infections are emerging in health due to antibiotic resistance. Thus, elucidating the mechanisms of their commensalism or pathogenicity in the gut complex is important. The dynamic network composed of the microbiota, metabolites, and immune system in the gut is essential in gut homeostasis and health. The gut microbiota is crucial for communication along the gut-brain axis as well as instructing proper local and systemic immune responses.
Key bacterial metabolites (i.e, short chain fatty acids, neurochemicals) are used by the gut microbiota to regulate host activities. However, the composition and functions of this gut microbiota (and more specifically, Enterobacteriaceae) are similarly-regulated by host effector molecules like neurochemicals, antimicrobial peptides, and antibodies. The aim of this Research Topic is to present a current and compelling collection reflecting novel research in this field, with a particular focus on the role of metabolites in the cross-talk between microbes and host and their role in Enterobacteriaceae colonization/infections.
We welcome original research papers, methods and review articles covering the neurometabolic and other metabolic pathways associated with immunological and genetic mechanisms of Enterobacteriaceae colonization and infections in humans and animals from a molecular biology perspective.
Keywords: Gut, Enterobacteriaceae, metabolites, neurotransmitters, immunity
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