Research Topic

Cellular Dormancy: State Determination and Plasticity

About this Research Topic

The vast majority of cells in the human body are dormant and non-dividing at any given moment. Some of these dormant cells, e.g. terminally differentiated cells and senescent cells, are permanently out of the cell cycle. Other dormant cells, namely quiescent cells that include adult stem cells and progenitor cells, can re-enter the cell cycle and proliferate in response to physiological cues. Organs and tissues are composed of various types of cells in different states of dormancy. These dormant cells play critical roles in tissue homeostasis, repair, and regeneration. Pathological changes in dormant cells can lead to numerous hyper- or hypo-proliferation diseases, including cancer, aging, fibrosis, anemia and autoimmunity. Dormant states are shaped by cellular networks of gene regulation, cell signaling, and metabolic reactions. These cellular networks integrate cellular signals from numerous inputs into the final determinants of cell dormancy. Cellular dormancy exhibits significant heterogeneity and plasticity, and the boundaries between these states are often blurred. We lack a clear understanding of what determines and shapes individual states of cellular dormancy and their variations.

In this article collection, we welcome both Original Research and Review articles that address the fascinating and complex states of cell dormancy, their distinctions and plasticity, in both human and model organisms. The proposed Research Topic aims to attract submissions related, but not limited, to the following areas:

• Mechanistic characterizations of cell dormancy
• Interactions and transitions across cell dormancy states
• Dysregulation of cell dormancy states in diseases
• Cellular markers that define and distinguish cell dormancy states
• Methods and tools to study cellular dormancy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The vast majority of cells in the human body are dormant and non-dividing at any given moment. Some of these dormant cells, e.g. terminally differentiated cells and senescent cells, are permanently out of the cell cycle. Other dormant cells, namely quiescent cells that include adult stem cells and progenitor cells, can re-enter the cell cycle and proliferate in response to physiological cues. Organs and tissues are composed of various types of cells in different states of dormancy. These dormant cells play critical roles in tissue homeostasis, repair, and regeneration. Pathological changes in dormant cells can lead to numerous hyper- or hypo-proliferation diseases, including cancer, aging, fibrosis, anemia and autoimmunity. Dormant states are shaped by cellular networks of gene regulation, cell signaling, and metabolic reactions. These cellular networks integrate cellular signals from numerous inputs into the final determinants of cell dormancy. Cellular dormancy exhibits significant heterogeneity and plasticity, and the boundaries between these states are often blurred. We lack a clear understanding of what determines and shapes individual states of cellular dormancy and their variations.

In this article collection, we welcome both Original Research and Review articles that address the fascinating and complex states of cell dormancy, their distinctions and plasticity, in both human and model organisms. The proposed Research Topic aims to attract submissions related, but not limited, to the following areas:

• Mechanistic characterizations of cell dormancy
• Interactions and transitions across cell dormancy states
• Dysregulation of cell dormancy states in diseases
• Cellular markers that define and distinguish cell dormancy states
• Methods and tools to study cellular dormancy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

29 January 2021 Abstract
21 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

29 January 2021 Abstract
21 April 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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