About this Research Topic
The cellular structures define the range of functional outcomes. For example, the three-dimensional chromatin organization contributes to the gene activity during the immune response and cell differentiation. The capacity of cells to change during differentiation or exposure to stress factors defines the life span and life quality of an organism. Recent break-thru in the development of genomic methods allows us to integrate the 3D nuclear organizations into the fourth dimension, the time. Such progress is critical for dissecting the dynamic changes within the nucleus as it leads to uncovering the new principles of chromatin organization, chromatin changes during the immune response, cell cycle, physiological stresses, and pathological conditions. The dynamics of nuclear organization highlight the main avenue in our understanding of cell biology during a healthy lifespan and disease.
The proposed Research Topic aims to integrate our current understanding of the dynamics of chromatin architecture during cardiovascular, metabolic, cell division, mechanic, and physiological stresses. The critical aspects not to be overlooked are the signal transduction pathways that mediate the connection between the external cues and chromatin alterations. The addition of time factor to the context of chromatin organization is possible due to the blooming variety of omics and imaging methods.
• Immune response and chromatin dynamics
• Differentiation and chromatin architecture
• Chromatin changes during cell division
• Physiological stresses and chromatin dynamics
• Signal transduction and chromatin alterations
• Cardiovascular disorders and chromatin alterations
• Metabolic syndrome and chromatin dynamics
• Chromatin dynamics in neurodegeneration
• Time-dependent nuclear organization dynamics and biomechanical stimuli
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