About this Research Topic
The biosynthesis of glycans is different from the biosynthesis of nucleic acid and proteins, which is a non-template-driven process. It is regulated by several heterogeneous factors, from cell types, to the species which cause the complex nature of protein glycosylation. Mass spectrometry (MS)is the most powerful tool for glycoprotein identification. However, the low abundance and poor ionization efficiency of glyco-proteins/peptides are the main obstacle in Mass Spectrometry-based glycosylation analysis. With the goal to understand and characterize protein glycosylation, we would like to encourage scientific discoveries, such as (1) novel glycan structure analysis and glycoprotein characterization methods, (2) protein glycosylation related databases and search engine development and (3) low organism protein glycosylation analysis, as well as (4) biological function analysis of protein glycosylation in disease.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Glycan modification analysis on glycoproteins, such as phosphorylation (Man6P) or sulfation
• Advanced characterization of O-glycosylated proteins, such as mucin-type O-glycosylation and O-GlcNAcylation
• Studies on the relationship between protein glycosylation and diseases, like 2019-nCov and cancer
• Reviews on glycoprotein characterization and glycan analysis using analytical techniques.
• Advanced analytical strategies for the high-throughput and automated characterization of site- or structure- specific glycosylation of proteins, like intact glycopeptide analysis, DIA method in glycoprotein analysis, and top-down glycoproteomics.
• Novel methodology for glycan-precise structure analysis
• Protein glycosylation analysis of low organisms, such as insects, plants and animals
• Development of glyco-related databases and search engines
Keywords: Glycomics, Glycoproteomics, Intact glycopeptides, Mass spectrometry, Glyco-related database
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.