About this Research Topic
Inflammation is the principal defense mechanism against microbial infection and host injury. Neutralization and elimination of the offending insult ideally prompts the resolution of inflammation and repair of damaged tissues. However, excessive or dysregulated inflammatory responses together with inadequate repair contribute to persisting tissue damage that underlies many inflammatory pathologies. Studies in the last 40 years established that resolution of inflammation involves tightly controlled self-limiting and active resolution circuits and that these circuits are also important in limiting autoimmunity and chronic inflammatory disorders. A growing number of effector molecules and cells that contribute to the effective resolution of inflammation have been identified. These effectors govern key events in the resolution of inflammation, such as inhibition of neutrophil influx, promotion of monocyte recruitment, redirecting neutrophils to apoptosis, rapid clearance of infiltrating neutrophils by phagocytes, reprogramming of macrophages and tissue cells, and regeneration of disrupted tissue architecture and composition.
The current Research Topic aims to update scientists studying the fields of Immunology, Biochemistry, Cell Biology, and Pathology with recent advancements in the field of resolution of inflammation. Particular focus will be given to novel molecules, signaling circuits, cell subsets, and functions involved in regulating various aspects of resolution. Autoimmune, inflammatory, and fibrotic diseases, such as rheumatoid arthritis, periodontitis, atherosclerosis, peritonitis, lung injury, bone loss, obesity, tissue fibrosis, and cancer, will be examined in the prism of resolution of inflammation and its pathogenic disruption. Innovative therapeutic applications of pro-resolutive agents in these disorders will also be of interest.
This Research Topic issue aims to gather contributions from attendees of the two recent “Resolution Days” meetings as well as contributions that are within the general theme of resolution of inflammation. We welcome both Original Research and Review articles focusing on, but not limited to, the following subtopics:
1. Specialized lipid mediators and protein effectors in resolution of inflammation
2. Signaling pathways activated by resolution cues
3. Tissue- and cell-specific aspects of resolution of inflammation.
4. Clearance of dead cells and resolution of inflammation
5. Metabolic and genomic changes pertaining to inflammation and resolution
6. Tissue imaging during inflammation and resolution
7. Resolution-inspired therapeutic approaches
Dr. Perruche is the CEO of MED’INN’PHARMA. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.