About this Research Topic
Autophagy, as an essential biological pathway with effects on immunity, is a powerful tool that host cells use to defend against bacterial and viral infection. Autophagy controls inflammation by interacting with the regulation of the innate immune signals, removing endogenous inflammasome agonists and affecting immune mediators to maintain cellular homeostasis. However, in an ongoing evolutionary arms race, several bacterial and viruses have acquired the potent ability to hijack and subvert autophagy for their benefit. In addition, the basic level autophagy has a protective effect on cells, excessive autophagy can also lead to autophagic cell death and even accelerate the progression of the disease. Therefore, study the regulation of autophagy activity during pathogenic microorganism infection can help us understand the mechanism of host disease-resistant microbial infection.
With the deepening study of autophagy, researchers have found that autophagy is involved in many immunological activities. This Research Topic will focus on the regulation of autophagy activity during different pathogenic microorganism infection, serving as the fundamental research in bacterial and viral diseases studies. In addition, there are still also some questions need to be answered: What is the relationship between pattern recognition receptors, autophagy and interferon responses? What is the relationship between autophagy, cellular oxidative stress and endoplasmic reticulum stress? What is the relationship between pathogenic microorganism infection, autophagy and cell death? What are the signaling pathways by which autophagy is activated by different pathogenic microorganisms? What is the mechanism by which some pathogenic microorganisms evade autophagic degradation?
Areas to be covered may include, but are not limited to:
• Different pattern recognition receptors activate autophagy signaling pathways
• Relationship between pattern recognition receptors, autophagy, inflammation and interferon responses
• Relationship between autophagy, oxidative stress and mitochondrial homeostasis
• Bacterial and viral evasion of autophagic degradation
• Autophagy and cell death
• Autophagy and cellular homeostasis
Keywords: Autophagy, Pathogenic Microorganism Infection, Immunity, Cell Signaling, Cellular Homeostasis
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