About this Research Topic
Next-generation sequencing (NGS) technologies have brought about unique opportunities to ameliorate the discovery of novel therapeutic targets, facilitate the precise design of clinical trials on target populations more likely to benefit from the treatment, and characterize novel indications of existing drugs. NGS, especially single-cell sequencing and spatial transcriptomics, will help effectively target matched drugs and provide new ideas for drug repositioning and anti-cancer therapy.
In this Research Topic, we aimed to bring together recent advances on drug repositioning in cancer therapy applying bioinformatics analysis combined with in vivo or in vitro validation, so to provide new evidence for anti-cancer therapy and to help realize the full potential of drug repurposing.
This Research Topic welcomes submissions of Original Research, Case Report, and Review articles that cover all aspects of the effects of drug repurposing on anti-cancer therapy, including but are not limited to the following topics:
• Using bioinformatics analysis and experimental validation to explore specific relevant driver alterations, molecular features, aberrant pathway which are targets of "old drugs".
• Using genomics data to explore novel tumor molecular subtypes that can be targeted by "old drugs" to develop precision cancer therapy.
• Using single-cell sequencing and spatial transcriptomics to explore tumor evolution, tumor microenvironment, tumor heterogeneity, drug resistance, and provide support for drug repurposing.
• Using molecular docking and molecular dramatics to explore the structure and function of aberrant genetic alteration and the fitness of anti-cancer drugs.
• Using integrative genomics (e.g., genomes, epigenomes, transcriptomes, regulomes, proteomes, and metabolomes) to explore drug repurposing in different types of tumors.
• Retrospective control study, retrospective cohort study, and clinical trials about drug repurposing are also considered.
Notably, manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in Frontiers in Oncology.
Keywords: Anti-Cancer Drugs, Drug Repositioning, Next-Generation Sequencing (NGS), Cancer Genomics, Single Cell and Bulk Genomics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.