Systems Biology has revolutionized the way scientists address the study of microorganisms, by looking globally, instead of partially. By using an integrative, systematic way, based on the analysis and modelling of large data sets, networks reflecting microbial functions and processes like metabolism or transcriptional regulation, and their associated mathematical models, can be build up.
While this holistic approach has been widely used for the study of mesophilic microorganisms, little is known about the application of Systems Biology to investigate the extremophilic side of microbial life, from their adaptive mechanisms to their biotechnological potential.
Extremophilic microorganisms (thermophiles, halophiles, piezophiles, psycrophiles, acidophiles, etc), show unusual properties and mechanisms to adapt their physiology to extreme environments. In addition, they synthetize valuable metabolites like extremozymes, extremolites, exopolysaccharides, biopolymers (bioplastics) o peptides, that find wide applications in diverse Biotechnology areas. They are also an unexploted source of novel genetic pathways which could be used for synthetic biology and metabolic engineering. Therefore, it is considered that this unique group of microorganisms offers/posseses a relevant potential for the development of Bioeconomy.
This Research Topic aims to get inside the study of extremophilic microorganisms (i.e., bacteria, archaea, microscopic algae and fungi), and their biotechnological applications, from a Systems Biology perspective. We are looking forward to gathering a collection of contributions describing from computational techniques to large-scale ‘omics’ experiments to address how extremophilic microbes strive under stress conditions (i.e. high or low temperature, high salinity, extreme pH or pressure), and how to biotechnologically exploit them.
Authors are encouraged to submit original research, methods, reviews and mini-reviews, as well as opinion articles, on the use of the following Systems Biology and omics approaches for extremophilic microorganisms:
• Omics analysis (i.e. transcriptomics, proteomics, metabolomics, fluxomics, interactomics), especially in combination.
• Integrative analysis of omics and metaomics data
• Genome-based metabolic reconstruction and modelling
• Global regulatory networks and/or regulatory models
• Modelling of other microbial processes
• Omics data integration into mathematical models
• Metaomics-driven analysis of extreme microbial communities: ecological relationships, microbial communities engineering, etc.
• Scaling-up in Systems Biology, integration of regulatory and metabolic models
*Contributions describing only genomic or metagenomics analyses are not recommended
Systems Biology has revolutionized the way scientists address the study of microorganisms, by looking globally, instead of partially. By using an integrative, systematic way, based on the analysis and modelling of large data sets, networks reflecting microbial functions and processes like metabolism or transcriptional regulation, and their associated mathematical models, can be build up.
While this holistic approach has been widely used for the study of mesophilic microorganisms, little is known about the application of Systems Biology to investigate the extremophilic side of microbial life, from their adaptive mechanisms to their biotechnological potential.
Extremophilic microorganisms (thermophiles, halophiles, piezophiles, psycrophiles, acidophiles, etc), show unusual properties and mechanisms to adapt their physiology to extreme environments. In addition, they synthetize valuable metabolites like extremozymes, extremolites, exopolysaccharides, biopolymers (bioplastics) o peptides, that find wide applications in diverse Biotechnology areas. They are also an unexploted source of novel genetic pathways which could be used for synthetic biology and metabolic engineering. Therefore, it is considered that this unique group of microorganisms offers/posseses a relevant potential for the development of Bioeconomy.
This Research Topic aims to get inside the study of extremophilic microorganisms (i.e., bacteria, archaea, microscopic algae and fungi), and their biotechnological applications, from a Systems Biology perspective. We are looking forward to gathering a collection of contributions describing from computational techniques to large-scale ‘omics’ experiments to address how extremophilic microbes strive under stress conditions (i.e. high or low temperature, high salinity, extreme pH or pressure), and how to biotechnologically exploit them.
Authors are encouraged to submit original research, methods, reviews and mini-reviews, as well as opinion articles, on the use of the following Systems Biology and omics approaches for extremophilic microorganisms:
• Omics analysis (i.e. transcriptomics, proteomics, metabolomics, fluxomics, interactomics), especially in combination.
• Integrative analysis of omics and metaomics data
• Genome-based metabolic reconstruction and modelling
• Global regulatory networks and/or regulatory models
• Modelling of other microbial processes
• Omics data integration into mathematical models
• Metaomics-driven analysis of extreme microbial communities: ecological relationships, microbial communities engineering, etc.
• Scaling-up in Systems Biology, integration of regulatory and metabolic models
*Contributions describing only genomic or metagenomics analyses are not recommended
