The Viral Evasion of Antiviral Innate Immunity

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University of Calgary

Center for Cancer Research, National Cancer Institute at Frederick

McGill University

Houston Methodist Research Institute

Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida

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Central to antiviral innate immune responses is the detection of evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs). Viral infection triggers the rapid induction of host innate immune responses. However, viruses have evolved multiple strategies to evade host innate responses and facilitate their infection.

In this Research Topic, we will incorporate the most recent findings on the molecular mechanisms utilized by viruses to counteract host antiviral innate immune responses with a specific focus on innate immune signaling pathways (RLR, TLR, and cGAS-STING mediated DNA sensing) resulting in type I interferon (IFN-I) production, IFN-I downstream IFNAR-JAK-STAT signal pathways and ISGs.

The type I interferon (IFN) signal pathway is a central aspect of host defense that induces a wide range of antiviral proteins to control infection of incoming pathogens. Innate immune responses also include DNA damage response, autophagy, endoplasmic reticulum stress, cytoplasmic stress granules, unfolded protein response (UPR), Apoptosis/necrosis/pyrosis/Pyroptosi, inflammasome, and other innate immune responses, which also affect viral infection. Our Research Topic will involve all viruses, including DNA and RNA viruses, and their immune evasion mechanisms for host antiviral innate immunity.

Types of manuscripts: all perspective articles include but are not limited to Original Research Article, Review, Mini review and Hypothesis, and Theory, etc.

Central to antiviral innate immune responses is the detection of evolutionarily conserved structures, termed pathogen-associated molecular patterns (PAMPs), by a set of germline-encoded pattern-recognition receptors (PRRs). Viral infection triggers the rapid induction of host innate immune responses. However, viruses have evolved multiple strategies to evade host innate responses and facilitate their infection.

In this Research Topic, we will incorporate the most recent findings on the molecular mechanisms utilized by viruses to counteract host antiviral innate immune responses with a specific focus on innate immune signaling pathways (RLR, TLR, and cGAS-STING mediated DNA sensing) resulting in type I interferon (IFN-I) production, IFN-I downstream IFNAR-JAK-STAT signal pathways and ISGs.

The type I interferon (IFN) signal pathway is a central aspect of host defense that induces a wide range of antiviral proteins to control infection of incoming pathogens. Innate immune responses also include DNA damage response, autophagy, endoplasmic reticulum stress, cytoplasmic stress granules, unfolded protein response (UPR), Apoptosis/necrosis/pyrosis/Pyroptosi, inflammasome, and other innate immune responses, which also affect viral infection. Our Research Topic will involve all viruses, including DNA and RNA viruses, and their immune evasion mechanisms for host antiviral innate immunity.

Types of manuscripts: all perspective articles include but are not limited to Original Research Article, Review, Mini review and Hypothesis, and Theory, etc.

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Editors

University of Calgary

Center for Cancer Research, National Cancer Institute at Frederick

McGill University

Houston Methodist Research Institute

Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida

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Frontiers in Microbiology

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Frontiers in Cellular and Infection Microbiology

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Frontiers in Plant Science

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