Many factors that affect breast cancer risk, such as hormones and lifestyle, can be modified, and it has been shown convincingly that targeting at least one or more of these will substantially delay and possibly prevent the onset of breast cancer (primary prevention). Various radiologic techniques can detect breast cancer long before the appearance of a mass in the breast or other symptoms of the disease, and randomized trials have shown that routine screening mammography in asymptomatic women will reduce breast cancer mortality in at least some populations (secondary prevention).
However, breast cancer consists of at least four molecular intrinsic subtypes (i.e., Luminal A, Luminal B, HER2-enriched and Basal-like [either BRCA-wild type or mutated]) and both primary and secondary prevention strategies may differ between subtypes in consideration of the different biological and clinical characteristics of each one. Furthermore, new insights in biology and cancer genetics suggest the potential role of novel molecular targeted molecules to be used as pharmacoprevention agents to delay or prevent carcinogenesis of breast cancer subtypes. Moreover, the evidenced-based patient-focused recommendations developed by the World Cancer Research Fund/American Institute for Cancer Research support patients' engagement and mindfulness on an adequate lifestyle with a personalized cancer-protective lifestyle prescription.
This Research Topic is dedicated to addressing advances in primary and secondary prevention of breast cancer, with a special focus on how different intrinsic breast cancer subtypes may be related to distinct risk factors and may, thus, respond to different prevention strategies.
We welcome Original Research, Clinical Trials, and Review articles focusing on but not limited to the following aspects:
· Breast cancer risk factors
· Breast cancer awareness and risk reduction
· Epidemiology and prevention methods
· New options for the prevention of hereditary breast and ovarian cancer
· Pharmacological prevention in high-risk women
· New insights in breast cancer screening
· Prediction of breast cancer molecular subtypes using radiomics signatures
· Molecular heterogeneity of breast cancer affecting prevention research and strategies
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Many factors that affect breast cancer risk, such as hormones and lifestyle, can be modified, and it has been shown convincingly that targeting at least one or more of these will substantially delay and possibly prevent the onset of breast cancer (primary prevention). Various radiologic techniques can detect breast cancer long before the appearance of a mass in the breast or other symptoms of the disease, and randomized trials have shown that routine screening mammography in asymptomatic women will reduce breast cancer mortality in at least some populations (secondary prevention).
However, breast cancer consists of at least four molecular intrinsic subtypes (i.e., Luminal A, Luminal B, HER2-enriched and Basal-like [either BRCA-wild type or mutated]) and both primary and secondary prevention strategies may differ between subtypes in consideration of the different biological and clinical characteristics of each one. Furthermore, new insights in biology and cancer genetics suggest the potential role of novel molecular targeted molecules to be used as pharmacoprevention agents to delay or prevent carcinogenesis of breast cancer subtypes. Moreover, the evidenced-based patient-focused recommendations developed by the World Cancer Research Fund/American Institute for Cancer Research support patients' engagement and mindfulness on an adequate lifestyle with a personalized cancer-protective lifestyle prescription.
This Research Topic is dedicated to addressing advances in primary and secondary prevention of breast cancer, with a special focus on how different intrinsic breast cancer subtypes may be related to distinct risk factors and may, thus, respond to different prevention strategies.
We welcome Original Research, Clinical Trials, and Review articles focusing on but not limited to the following aspects:
· Breast cancer risk factors
· Breast cancer awareness and risk reduction
· Epidemiology and prevention methods
· New options for the prevention of hereditary breast and ovarian cancer
· Pharmacological prevention in high-risk women
· New insights in breast cancer screening
· Prediction of breast cancer molecular subtypes using radiomics signatures
· Molecular heterogeneity of breast cancer affecting prevention research and strategies
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.