About this Research Topic
Crohn’s Disease is a chronic, idiopathic and disabling disorder which can virtually affect every part of the gastrointestinal system.
From a pathologic point of view, it is characterized by transmural inflammation, involving other than the mucosa and the submucosa, even the muscular and serosal layer of the bowel wall. The subsequent structural bowel damage can lead to complications such as strictures, fistulas and abscesses , often requiring surgery.
Fistulising Crohn’s Disease, both involving the bowel or the anal canal, may often represent a challenging clinical situation, requiring multimodal strategies to optimize and individualize treatment.
The current Research Topic aims to address both the diagnostic and therapeutic controversies concerning fistulising Crohn’s Disease.
Research and review articles encompassing diagnostic modalities for abdominal Crohn’s Disease, including frontiers in the field of bowel sonography, MRI or CT scan as well as percutaneous techniques as bridge to surgery will perfectly fall within the aims of the Research Topic.
Surgical approach, novel techniques and multidisciplinary decision-making will be also widely discussed within the Topic.
A special section on perianal Crohn’s Disease will address novelties in the “biosurgical” approach, including the promises by stem cell therapy.
A focus on basic research articles , molecular mechanisms of the disease and medical therapy will be also included.
Accepted submissions will include original papers, narrative reviews and meta-analysis and technical notes.
As abovementioned, manuscripts encompassing diagnostic issues , medical and surgical treatment modalities in both abdominal and perianal fistulizing Crohn’s Disease will be considered suitable for publication in the current Research Topic.
Conflict Of Interest Statement: Gaetano Luglio has been in the advisory board for Takeda and Janseen.
Keywords: Crohn's disease, fistulising disesase, perianal crohn's disease, IBD, abdominal abscess
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.