Cell adhesion, communication (intercellular, paracellular, and intracellular) and cell migration are key contributing factors to the metastatic spread of cancer cells (metastasis). The current issue focuses on the theme of cell adhesives and migration and invites articles exploring the cellular and molecular mechanisms underlying cell adhesion and cellular migration, molecular signaling, and strategies targeting cancer and metastasis-related adhesion molecules and motogens (motility factors) by small molecules (natural or synthetic) and other recent technologies, including CRISPR. Description of new methods in studying these cellular processes are also welcome.
We invite the submission of Original Research and Review articles on themes including, but not limited to:
- ALCAM/CD166; its role in skeletal metastasis
- Targeting FAK/paxillin; a prospective role in controlling cancer cell migration
- LIMA1 and LIMK; their role in regulating cytoskeleton and cellular migration
- Claudins; their role in barrier function and paracellular permeability of cancer cells
- AF6; its role in junctional functions
- PTPR and PRPK; from intracellular phosphatases to cell-cell adhesion cancer
- CCL-18; receptor signaling in cancer
- CCLs; their role in cancer progression
- Motogens (motility factors); their role in cancer cell migration
- CTNNs; their role in cell migration and progression of cancer
- DRIM, genes lost in cancer; their role in cell migration and metastasis
- Endothelial enriched adhesion molecules, TEM8 and CMG2; their role in cancer
- DHX family; how it regulates and interacts with cell adhesion complexes in cancer
Keywords: Cell adhesion molecules, Cell communications, Tight junctions, Cellular Migration, Cancer
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
