The Role of non-coding RNAs in Gastrointestinal Cancers

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Editorial

08 November 2022

Editorial: The role of non-coding RNAs in gastrointestinal cancer

Divya P. Kumar

,

Kanjoormana Aryan Manu

and

Muzafar Ahmad Macha

1,058 views

1 citations

Editors

3

Kanjoormana Aryan Manu

Amala Cancer Research Centre

Divya P Kumar

JSS Medical College & Hospital, JSS Academy of Higher Education and Research

Dr. MUZAFAR AHMAD MACHA

Watson-Crick Centre for Molecular Medicine, Islamic University of Science and Technology, Awantipora, Kashmir, India-192122

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Gastrointestinal malignancies encompass a large number of tumor types, and collectively are responsible for a significant portion of new cancer cases annually. According to the IARC database, colorectal cancer alone is responsible for approximately 10% of new cases of cancer worldwide annually. There is significant heterogeneity across the various tumor types, with different pathways and factors involved in oncogenesis, as well as varying degrees of prognosis depending on the tumor type.

Non-coding RNAs (ncRNAs) contribute to a significant portion of the human transcriptome, and of particular interest are the micro-RNAs (miRNAs), long ncRNAs (lncRNAs), and circular ncRNAs (circRNAs). With the advent of next-generation sequencing and new technologies such a minimally invasive biopsy techniques, there is a growing body of evidence elucidating the role of ncRNAs in the progression of various form of gastrointestinal cancers. Furthermore, in addition to their relevance to cancer progression, these ncRNAs have important potential as biomarkers and prognostic markers for various GI cancers.

This Research Topic aims to provide insight into the role of ncRNAs in GI cancers in, but not limited to, the following areas:
• ncRNAs as prognostic and diagnostic markers
• ncRNAs role in tumor progression
• ncRNAs as predictors for drug response
• Novel technologies related to studying ncRNAs
• Precision medicine involving ncRNAs

Please note: The findings based on omics data integration should be also supported by observational/experimental data. Descriptive studies and studies consisting only of bioinformatic investigation of accessible genomic or transcriptomic data do not fall within the scope of the journal.

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Editors

Kanjoormana Aryan Manu

Amala Cancer Research Centre

Divya P Kumar

JSS Medical College & Hospital, JSS Academy of Higher Education and Research

Dr. MUZAFAR AHMAD MACHA

Watson-Crick Centre for Molecular Medicine, Islamic University of Science and Technology, Awantipora, Kashmir, India-192122

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1,049 Topic views

Published In

Frontiers in Oncology

Gastrointestinal Cancers: Colorectal Cancer, Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers, Gastrointestinal Cancers: Gastric and Esophageal Cancers, Gastrointestinal Cancers

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