About this Research Topic
Cancer is still a top leading cause of death worldwide. Ineffective treatments, severe side effects, drug resistance, recurrence, and metastasis are major barriers to curing cancers. Latest therapies targeting tumor microenvironment show promise. Unexpectedly, limited cancer patients response to the latest PD-L1 targeted immunotherapies, and the underlying mechanism is still unclear.
In fact, cancer is catalogued as an inflammatory disease. Increasing evidence reveal the involvement of fibrotic signaling, e.g. TGF-beta and NF-kB signaling, in the cancer development. A better understanding of how pathogenic signalings from the tissue fibrosis contributing to the tumorigenesis would uncover novel pathogenic mechanisms and therapeutic targets for cancer.
This Research Topic serves as an interactive platform for sharing the latest insights of molecular mechanisms, translational potential, and clinical observations of the tumor microenvironment with advanced research strategies for cancer. Original Research, Review, Mini-Review, Clinical Trial, and Perspective articles covering the listed areas are welcome:
1) New emerging roles for fibrotic signaling in cancer development
2) Pathogenic functions of mechanisms from the tissue fibrosis in cancer
3) Novel approaches for dissecting the fibrotic signaling in cancer progression and drug resistance
4) Fibrotic signaling in cancer immunology
5) Latest therapeutic approaches for targeting the fibrotic signaling in cancer
Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Keywords: Fibrosis, Signaling, Drug Resistence
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.