Research Topic

Adhesion Molecules and Autoimmune Diseases

About this Research Topic

The activation, migration, and recruitment of immune cells to inflammatory sites depend on their interaction with adhesion molecules of other cells or extracellular matrix ligands. Leukocyte adhesion molecules, such as integrins, members of the immunoglobulin superfamily, selectins, and cadherins, play crucial roles in mediating these processes. In particular, integrins play crucial roles in regulating various aspects of immune cell function, including cell circulation, lymphoid tissue homing, trans-endothelial migration and persistence, effector cell activation and proliferation, and the formation of immune synapses between immune cells or with target cells during homeostasis and inflammation.

During the development of autoimmune diseases, a large number of adhesion interactions occur between immunocompetent cells, endothelium, extracellular matrix, and the target tissue. The adhesion molecules promote leukocyte adhesion and extravasation from the circulation into inflamed tissues. Elevated levels of adhesion molecules was found in systemic lupus erythematosus (SLE) patients. Antibodies that block the association between integrins and ligands have shown significant efficacy in autoimmune disease, including multiple sclerosis and inflammatory bowel disease. Further characterization of the migration and adhesion pattern of immune cells should clarify the pathogenesis of specific autoimmune diseases and identify potential therapeutic targets.

This Research Topic aims to collect studies regarding adhesion molecule function, regulation of immune cell adhesion and recruitment, and characterization of adhesion receptors in autoimmune diseases, such as inflammatory bowel disease, rheumatoid arthritis (RA), systemic lupus erythematosus, Sjögren's syndrome, autoimmune thyroid disease, multiple sclerosis, and diabetes mellitus. We welcome the submission of Review, Original Research, Perspective, Clinical Trial and Case Report articles covering, but not limited to, the following sub-topics:

1. The function of adhesion molecules in immune cell activation, migration, and recruitment.

2. Structure and function of adhesion molecules

3. Adhesion molecules in the development of autoimmune diseases

4. Therapeutic targeting of adhesion molecules in autoimmune diseases

5. Advanced imaging of immune cell locomotion and recruitment in autoimmune diseases


Keywords: adhesion molecules, integrin, autoimmune diseases, migration, recruitment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The activation, migration, and recruitment of immune cells to inflammatory sites depend on their interaction with adhesion molecules of other cells or extracellular matrix ligands. Leukocyte adhesion molecules, such as integrins, members of the immunoglobulin superfamily, selectins, and cadherins, play crucial roles in mediating these processes. In particular, integrins play crucial roles in regulating various aspects of immune cell function, including cell circulation, lymphoid tissue homing, trans-endothelial migration and persistence, effector cell activation and proliferation, and the formation of immune synapses between immune cells or with target cells during homeostasis and inflammation.

During the development of autoimmune diseases, a large number of adhesion interactions occur between immunocompetent cells, endothelium, extracellular matrix, and the target tissue. The adhesion molecules promote leukocyte adhesion and extravasation from the circulation into inflamed tissues. Elevated levels of adhesion molecules was found in systemic lupus erythematosus (SLE) patients. Antibodies that block the association between integrins and ligands have shown significant efficacy in autoimmune disease, including multiple sclerosis and inflammatory bowel disease. Further characterization of the migration and adhesion pattern of immune cells should clarify the pathogenesis of specific autoimmune diseases and identify potential therapeutic targets.

This Research Topic aims to collect studies regarding adhesion molecule function, regulation of immune cell adhesion and recruitment, and characterization of adhesion receptors in autoimmune diseases, such as inflammatory bowel disease, rheumatoid arthritis (RA), systemic lupus erythematosus, Sjögren's syndrome, autoimmune thyroid disease, multiple sclerosis, and diabetes mellitus. We welcome the submission of Review, Original Research, Perspective, Clinical Trial and Case Report articles covering, but not limited to, the following sub-topics:

1. The function of adhesion molecules in immune cell activation, migration, and recruitment.

2. Structure and function of adhesion molecules

3. Adhesion molecules in the development of autoimmune diseases

4. Therapeutic targeting of adhesion molecules in autoimmune diseases

5. Advanced imaging of immune cell locomotion and recruitment in autoimmune diseases


Keywords: adhesion molecules, integrin, autoimmune diseases, migration, recruitment


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2021 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2021 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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