Research Topic

Immunological Mechanisms and Therapeutic Approaches for Lung Transplant Rejection

About this Research Topic

Lung transplantation is an increasingly used therapy for end-stage lung diseases. However, the long-term outcomes after lung transplantation remain significantly unsatisfactory compared with those in the recipients of other solid-organ transplant. In the modern era of lung transplantation, the 5-year survival rate is only about 50%. One of the key reasons is the unique anatomic and immunological properties of lungs. They constantly interact with pathogens as well as environmental antigens. Recent advances of innate cells (e.g. monocytes, macrophages and neutrophils etc.) and their critical roles in early graft dysfunction as well as chronic rejection, especially the new knowledge in the field of trained innate immunity and adaptive memory responses, have dramatically changed our understanding of lung immunology and the strategies to achieve long-term graft acceptances.

This Research Topic aims to advance the knowledge of lung transplant immunology, specifically the innate immunity and its trained response, adaptive memory response and heterologous immunity, and their roles in primary graft dysfunction (PGD), acute and chronic rejection, to gain new perspectives of lung transplant protection and to develop novel strategies for long-term graft survival.

We welcome submissions of Original Research, Review, Mini Review on the sub-topics below:

1. Primary graft dysfunction (PGD) after lung transplantation
a. Ischemia-reperfusion injury, mitochondria-derived DAMPs, high mobility group box 1 (HMGB1), etc.
b. Neutrophils and/or neutrophil extracellular traps (NETs), DNAs/extracellular histones
c. IL-17 and Inflammation
d. Autophagy

2. Memory of innate cells in lung transplantation
a. Adaptive features of innate immune cells
b. Trained immunity
c. Efferocytosis
d. Macrophage polarization
e. Macrophage subtypes, fibrosis and chronic rejection

3. Adaptive immunity in lung transplantation
a. Th and/or CTL responses to alloantigens
b. Regulatory T cells (Tregs)
c. Antibody-mediated rejection (AMR)

4. Memory T cells in lung transplantation
a. Heterologous immunity
b. CD28- memory T cells
c. Resistance to tolerization

5. Novel approaches for long-term lung transplant survival
a. New preservation solutions and methods
b. Immunologic, metabolic and epigenetic approaches that target trained immunity to modulate immune response
c. Therapeutic strategies of targeting memory T cells to alter their properties


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Lung transplantation is an increasingly used therapy for end-stage lung diseases. However, the long-term outcomes after lung transplantation remain significantly unsatisfactory compared with those in the recipients of other solid-organ transplant. In the modern era of lung transplantation, the 5-year survival rate is only about 50%. One of the key reasons is the unique anatomic and immunological properties of lungs. They constantly interact with pathogens as well as environmental antigens. Recent advances of innate cells (e.g. monocytes, macrophages and neutrophils etc.) and their critical roles in early graft dysfunction as well as chronic rejection, especially the new knowledge in the field of trained innate immunity and adaptive memory responses, have dramatically changed our understanding of lung immunology and the strategies to achieve long-term graft acceptances.

This Research Topic aims to advance the knowledge of lung transplant immunology, specifically the innate immunity and its trained response, adaptive memory response and heterologous immunity, and their roles in primary graft dysfunction (PGD), acute and chronic rejection, to gain new perspectives of lung transplant protection and to develop novel strategies for long-term graft survival.

We welcome submissions of Original Research, Review, Mini Review on the sub-topics below:

1. Primary graft dysfunction (PGD) after lung transplantation
a. Ischemia-reperfusion injury, mitochondria-derived DAMPs, high mobility group box 1 (HMGB1), etc.
b. Neutrophils and/or neutrophil extracellular traps (NETs), DNAs/extracellular histones
c. IL-17 and Inflammation
d. Autophagy

2. Memory of innate cells in lung transplantation
a. Adaptive features of innate immune cells
b. Trained immunity
c. Efferocytosis
d. Macrophage polarization
e. Macrophage subtypes, fibrosis and chronic rejection

3. Adaptive immunity in lung transplantation
a. Th and/or CTL responses to alloantigens
b. Regulatory T cells (Tregs)
c. Antibody-mediated rejection (AMR)

4. Memory T cells in lung transplantation
a. Heterologous immunity
b. CD28- memory T cells
c. Resistance to tolerization

5. Novel approaches for long-term lung transplant survival
a. New preservation solutions and methods
b. Immunologic, metabolic and epigenetic approaches that target trained immunity to modulate immune response
c. Therapeutic strategies of targeting memory T cells to alter their properties


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

22 September 2021 Abstract
01 February 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

22 September 2021 Abstract
01 February 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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