Research Topic

Impact of Tumor Microenvironment on the Maintenance of Colorectal Cancer Stem Cells

About this Research Topic

Numerous studies have demonstrated critical roles of tumor microenvironment in colorectal cancer initiation, progression, metastasis and therapy, which are majorly attributable to cancer stem cells. For instance, the tumor microenvironment heterogeneity, the interaction or crosstalk between cancer epithelial cells and stromal cells, including tumor-associated fibroblasts, immune cells, and their secretion of growth factors, colony stimulating factors, chemokines and cytokines, significantly influence the maintenance of cancer stem cells and cancer cell growth, progress, metastasis, and impact response to chemotherapy and immune-therapy. Moreover, gain of function in somatic mutations and the chronic inflammatory environment caused- transformation and tumor initiation are also linked to cancer stem cells. However, the underlying mechanisms are largely unknown. This issue focuses on the colorectal cancer microenvironment to reveal the impact of tumor microenvironment on the maintenance of colorectal cancer stem cells and consequently in colorectal cancer initiation, progression, metastasis and targeted therapies.

The goal of this Research Topic is to reveal the impact of tumor microenvironment on the maintenance of colorectal cancer stem cells and the underlying mechanism of colorectal carcinogenesis, chemoprevention strategy, immunotherapy and targeted therapies, to improve our understanding of the crucial functions of tumor microenvironment in cancer diagnosis, personalized therapy and prevention.

The scope of the Research Topic includes the impact of tumor microenvironment on the maintenance of colorectal cancer stem cells, the molecular regulation or regulatory network of cancer stem cells in colorectal cancer development, progression and metastasis. Additionally, the crosstalk between epithelial cells and stromal cells, extracellular matrix remodelling, immune cell activation, therapeutic targets and biomarkers identification, which are related to cancer stem cells, are also considerable. The types of manuscript include Research Article, Review, in particular, the findings or advances from high-throughput gene profiling, metabolomics, proteomics, immunotherapy, and novel biomarkers or targets identification for tumor microenvironment of colorectal cancer and precision medicine.

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.


Keywords: colorectal cancer, microenvironment, molecular regulation, tumor immunology, precision oncology, immunotherapy, biomarkers, stem cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Numerous studies have demonstrated critical roles of tumor microenvironment in colorectal cancer initiation, progression, metastasis and therapy, which are majorly attributable to cancer stem cells. For instance, the tumor microenvironment heterogeneity, the interaction or crosstalk between cancer epithelial cells and stromal cells, including tumor-associated fibroblasts, immune cells, and their secretion of growth factors, colony stimulating factors, chemokines and cytokines, significantly influence the maintenance of cancer stem cells and cancer cell growth, progress, metastasis, and impact response to chemotherapy and immune-therapy. Moreover, gain of function in somatic mutations and the chronic inflammatory environment caused- transformation and tumor initiation are also linked to cancer stem cells. However, the underlying mechanisms are largely unknown. This issue focuses on the colorectal cancer microenvironment to reveal the impact of tumor microenvironment on the maintenance of colorectal cancer stem cells and consequently in colorectal cancer initiation, progression, metastasis and targeted therapies.

The goal of this Research Topic is to reveal the impact of tumor microenvironment on the maintenance of colorectal cancer stem cells and the underlying mechanism of colorectal carcinogenesis, chemoprevention strategy, immunotherapy and targeted therapies, to improve our understanding of the crucial functions of tumor microenvironment in cancer diagnosis, personalized therapy and prevention.

The scope of the Research Topic includes the impact of tumor microenvironment on the maintenance of colorectal cancer stem cells, the molecular regulation or regulatory network of cancer stem cells in colorectal cancer development, progression and metastasis. Additionally, the crosstalk between epithelial cells and stromal cells, extracellular matrix remodelling, immune cell activation, therapeutic targets and biomarkers identification, which are related to cancer stem cells, are also considerable. The types of manuscript include Research Article, Review, in particular, the findings or advances from high-throughput gene profiling, metabolomics, proteomics, immunotherapy, and novel biomarkers or targets identification for tumor microenvironment of colorectal cancer and precision medicine.

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.


Keywords: colorectal cancer, microenvironment, molecular regulation, tumor immunology, precision oncology, immunotherapy, biomarkers, stem cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

04 September 2021 Abstract
02 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

04 September 2021 Abstract
02 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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