Cardiovascular disease (CVD) is a global challenge in modern society. Atherosclerosis has become the leading cause of CVD resulting in a high rate of mortality and disability. Significant progress has been made in the pathophysiology of atherosclerotic lesion formation and complications such as myocardial infarction, stroke, and peripheral vascular disease. Yet, despite these advances, therapeutic options that can significantly reduce morbidity and mortality remain limited, indicating the mechanism of atherosclerosis is still to be elucidated. Therefore, understanding the molecular mechanisms and discovering novel therapeutic targets for atherosclerosis are urgently needed for the development of effective treatments for heart diseases.
Understanding the mechanisms involved in the development of atherosclerosis is challenging due to the complexity of today’s picture of the pathogenesis of atherosclerosis. The molecular factors of atherosclerosis including renin-angiotensin signaling, vascular endothelial injury, lipid accumulation, smooth muscle cell phenotypic transition, macrophage infiltration, and inflammation alone or in combination contribute to the progress of atherosclerosis. In this Research Topic of Frontiers in Cardiovascular Medicine, we encourage submissions that identify possible mechanisms for the prevention of progression of atherosclerosis. Clinical research for the early diagnosis and prognosis of atherosclerosis-related diseases will also be welcomed.
We welcome submissions focusing on but not limited to topics below:
1) The role of the renin-angiotensin-aldosterone system in atherosclerosis and/or underlying cellular and molecular mechanisms.
2) Role of vascular endothelial injury in the development of atherosclerosis.
3) Regulation of the inflammatory response in atherosclerosis.
4) Novel molecular factors as a potential target in atherosclerosis treatment.
5) Clinical research on novel biomarkers for early diagnosis and prognosis of cardiac diseases.
Cardiovascular disease (CVD) is a global challenge in modern society. Atherosclerosis has become the leading cause of CVD resulting in a high rate of mortality and disability. Significant progress has been made in the pathophysiology of atherosclerotic lesion formation and complications such as myocardial infarction, stroke, and peripheral vascular disease. Yet, despite these advances, therapeutic options that can significantly reduce morbidity and mortality remain limited, indicating the mechanism of atherosclerosis is still to be elucidated. Therefore, understanding the molecular mechanisms and discovering novel therapeutic targets for atherosclerosis are urgently needed for the development of effective treatments for heart diseases.
Understanding the mechanisms involved in the development of atherosclerosis is challenging due to the complexity of today’s picture of the pathogenesis of atherosclerosis. The molecular factors of atherosclerosis including renin-angiotensin signaling, vascular endothelial injury, lipid accumulation, smooth muscle cell phenotypic transition, macrophage infiltration, and inflammation alone or in combination contribute to the progress of atherosclerosis. In this Research Topic of Frontiers in Cardiovascular Medicine, we encourage submissions that identify possible mechanisms for the prevention of progression of atherosclerosis. Clinical research for the early diagnosis and prognosis of atherosclerosis-related diseases will also be welcomed.
We welcome submissions focusing on but not limited to topics below:
1) The role of the renin-angiotensin-aldosterone system in atherosclerosis and/or underlying cellular and molecular mechanisms.
2) Role of vascular endothelial injury in the development of atherosclerosis.
3) Regulation of the inflammatory response in atherosclerosis.
4) Novel molecular factors as a potential target in atherosclerosis treatment.
5) Clinical research on novel biomarkers for early diagnosis and prognosis of cardiac diseases.
