In response to foreign threats or original ontogenesis, immune cells must enter and adapt to life within diverse tissues. Immune cells develop within dedicated immune system organs, such as the bone marrow, thymus and lymphoid tissues, and are anatomically localized in diverse sites in a tissue-specific manner, named tissue-resident immune cells (TRICs). They mainly include resident memory T, innate lymphoid cells, macrophages, natural killer and natural killer T cells, non-classical T cells, and memory B cells. These site-specific immune cell compositions reflect their distinct localization within tissue niches. They form an integral part of the immune sensing network, monitor local perturbations in homeostasis throughout the body, and defend against malignancies. However, the potential mechanisms underlying TRICs to host anti-tumor immune response remain unclear. Furthermore, immunotherapy has allowed the field of oncology to turn a critical corner. And TRICs may be major candidates for therapeutic manipulation. Therefore, decipherment of the function of TRICs on progressive disease is urgently required.
This research topic focuses on the interaction of tissue-resident immune cells and cancer progression to decipher the origins and biology of tissue-resident immune cells and the function of tissue-resident immune cells in tumorigenesis and malignant progression. Addressing these issues will apply this knowledge on the fundamental cell biology/pathophysiology of tissue-resident immune cells to cancer and develop targeted strategies to comprehend, prevent, or treat cancer following a continuum to translational and clinical research.
Contributions addressing the effects and mechanisms of TRICs in cancer are welcome for this research topic, including original articles presenting new findings and reviews summarizing the field's advances. Specific themes include, but are not limited to:
• The origins and biology of TRICs in tumor microenvironment
• Innate immunity and TRICs
• Adaptive immunity and TRICs
• Immunosurveillance and TRICs
• Immune recognition and TRICs
• Immune evasion and TRICs
• Immune memory and TRICs
In response to foreign threats or original ontogenesis, immune cells must enter and adapt to life within diverse tissues. Immune cells develop within dedicated immune system organs, such as the bone marrow, thymus and lymphoid tissues, and are anatomically localized in diverse sites in a tissue-specific manner, named tissue-resident immune cells (TRICs). They mainly include resident memory T, innate lymphoid cells, macrophages, natural killer and natural killer T cells, non-classical T cells, and memory B cells. These site-specific immune cell compositions reflect their distinct localization within tissue niches. They form an integral part of the immune sensing network, monitor local perturbations in homeostasis throughout the body, and defend against malignancies. However, the potential mechanisms underlying TRICs to host anti-tumor immune response remain unclear. Furthermore, immunotherapy has allowed the field of oncology to turn a critical corner. And TRICs may be major candidates for therapeutic manipulation. Therefore, decipherment of the function of TRICs on progressive disease is urgently required.
This research topic focuses on the interaction of tissue-resident immune cells and cancer progression to decipher the origins and biology of tissue-resident immune cells and the function of tissue-resident immune cells in tumorigenesis and malignant progression. Addressing these issues will apply this knowledge on the fundamental cell biology/pathophysiology of tissue-resident immune cells to cancer and develop targeted strategies to comprehend, prevent, or treat cancer following a continuum to translational and clinical research.
Contributions addressing the effects and mechanisms of TRICs in cancer are welcome for this research topic, including original articles presenting new findings and reviews summarizing the field's advances. Specific themes include, but are not limited to:
• The origins and biology of TRICs in tumor microenvironment
• Innate immunity and TRICs
• Adaptive immunity and TRICs
• Immunosurveillance and TRICs
• Immune recognition and TRICs
• Immune evasion and TRICs
• Immune memory and TRICs
