Research Topic

Metabolic Regulation of Gamete Function in Health and Disease

About this Research Topic

Fertilization is a key process in which two highly specialized cells, the sperm and the egg, interact and fuse to merge their haploid genomes to initiate the development of a new individual. Generally sperm must leave the body in which they were produced and move to meet the female gamete, while oocytes must prepare to support the early stages of embryonic development. In all cases, production of male and female gametes, as well as the fertilization process, are highly regulated events. Therefore, the correct functionality of both types of gametes can be influenced not only by their own metabolism but also by the gonadal and systemic metabolic conditions.

Recent studies have shown that life-style conditions of the individuals and different pathological metabolic conditions, such as polycystic ovarian syndrome (PCOS), metabolic syndrome, diabetes mellitus and ageing, may influence gonadal and gamete performance. In view of this, the goal of this Research Topic is to understand how the systemic or cellular metabolic activities regulate male and female gonads and gametes functionality. For this purpose, this Research Topic will provide a space in which the scientific community can present and discuss the findings and mechanisms that underlie the influence of metabolism on the preparation of gametes to produce viable offspring. The collection is open to articles covering all species, including vertebrate and invertebrate models and humans.

We welcome the submission of Original Research Articles, Reviews, Mini-Reviews, Brief Research Report, and Perspective articles. The areas to be covered in this Research Topic may include, but are not limited to:

-Role of the reproductive organ metabolism on sperm or egg functions, interaction or early development.
- Sperm metabolic pathways during their maturation and capacitation.
- Metabolic pathways during folliculogenesis, oocyte maturation, ovulation and egg activation.
- Effect of sperm or egg metabolic pathways on gamete interaction or early embryo development.
- Influence of metabolic disorders on male and female reproductive tract.
- Influence of metabolic disorders on sperm production, maturation and capacitation.
- Influence of metabolic disorders on follicle development, oocyte maturation and ovulation.
- Influence of metabolic disorders on gamete interaction or early embryo development.


Keywords: sperm, eggs, gonads, metabolism, fertilization, embryo development


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Fertilization is a key process in which two highly specialized cells, the sperm and the egg, interact and fuse to merge their haploid genomes to initiate the development of a new individual. Generally sperm must leave the body in which they were produced and move to meet the female gamete, while oocytes must prepare to support the early stages of embryonic development. In all cases, production of male and female gametes, as well as the fertilization process, are highly regulated events. Therefore, the correct functionality of both types of gametes can be influenced not only by their own metabolism but also by the gonadal and systemic metabolic conditions.

Recent studies have shown that life-style conditions of the individuals and different pathological metabolic conditions, such as polycystic ovarian syndrome (PCOS), metabolic syndrome, diabetes mellitus and ageing, may influence gonadal and gamete performance. In view of this, the goal of this Research Topic is to understand how the systemic or cellular metabolic activities regulate male and female gonads and gametes functionality. For this purpose, this Research Topic will provide a space in which the scientific community can present and discuss the findings and mechanisms that underlie the influence of metabolism on the preparation of gametes to produce viable offspring. The collection is open to articles covering all species, including vertebrate and invertebrate models and humans.

We welcome the submission of Original Research Articles, Reviews, Mini-Reviews, Brief Research Report, and Perspective articles. The areas to be covered in this Research Topic may include, but are not limited to:

-Role of the reproductive organ metabolism on sperm or egg functions, interaction or early development.
- Sperm metabolic pathways during their maturation and capacitation.
- Metabolic pathways during folliculogenesis, oocyte maturation, ovulation and egg activation.
- Effect of sperm or egg metabolic pathways on gamete interaction or early embryo development.
- Influence of metabolic disorders on male and female reproductive tract.
- Influence of metabolic disorders on sperm production, maturation and capacitation.
- Influence of metabolic disorders on follicle development, oocyte maturation and ovulation.
- Influence of metabolic disorders on gamete interaction or early embryo development.


Keywords: sperm, eggs, gonads, metabolism, fertilization, embryo development


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

26 September 2021 Abstract
27 March 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

26 September 2021 Abstract
27 March 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..