About this Research Topic
Fertilization is a key process in which two highly specialized cells, the sperm and the egg, interact and fuse to merge their haploid genomes to initiate the development of a new individual. Generally sperm must leave the body in which they were produced and move to meet the female gamete, while oocytes must prepare to support the early stages of embryonic development. In all cases, production of male and female gametes, as well as the fertilization process, are highly regulated events. Therefore, the correct functionality of both types of gametes can be influenced not only by their own metabolism but also by the gonadal and systemic metabolic conditions.
Recent studies have shown that life-style conditions of the individuals and different pathological metabolic conditions, such as polycystic ovarian syndrome (PCOS), metabolic syndrome, diabetes mellitus and ageing, may influence gonadal and gamete performance. In view of this, the goal of this Research Topic is to understand how the systemic or cellular metabolic activities regulate male and female gonads and gametes functionality. For this purpose, this Research Topic will provide a space in which the scientific community can present and discuss the findings and mechanisms that underlie the influence of metabolism on the preparation of gametes to produce viable offspring. The collection is open to articles covering all species, including vertebrate and invertebrate models and humans.
We welcome the submission of Original Research Articles, Reviews, Mini-Reviews, Brief Research Report, and Perspective articles. The areas to be covered in this Research Topic may include, but are not limited to:
-Role of the reproductive organ metabolism on sperm or egg functions, interaction or early development.
- Sperm metabolic pathways during their maturation and capacitation.
- Metabolic pathways during folliculogenesis, oocyte maturation, ovulation and egg activation.
- Effect of sperm or egg metabolic pathways on gamete interaction or early embryo development.
- Influence of metabolic disorders on male and female reproductive tract.
- Influence of metabolic disorders on sperm production, maturation and capacitation.
- Influence of metabolic disorders on follicle development, oocyte maturation and ovulation.
- Influence of metabolic disorders on gamete interaction or early embryo development.
Keywords: sperm, eggs, gonads, metabolism, fertilization, embryo development
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.