About this Research Topic
The microbial metabolome is a reflection of a microbe’s metabolism, defined by the biosynthetic pathways and networks encoded in its genome and regulated by its host and environmental context. The analysis of the metabolome provides an assessment of the cellular state and gene function in a microbial system, revealing regulatory mechanisms and providing a deeper insight into cellular physiology, a better understanding of environmental effects on system function, and an assessment of the global outcome of interactions between microbial cells, their (human) host and their environment. Moreover, metabolomics permits identifying specific biomarker molecules associated with structural and metabolic states. Microbial metabolomics is an essential component of the ‘omics’ approaches applied in system biology, the metabolomic data offering essential input to metabolic models that are helping to better describe the microbial metabolic plasticity and regulation.
This article collection aims to address the most relevant current research on the application of microbial metabolomics to challenges in microbial physiology, secondary metabolite expression and regulation, biosynthesis of natural products, and metabolic modeling and engineering. Contributions on the metabolomic characterization of complex microbial communities, including the interaction between the human microbiome and its host, are also welcome, as are discussions of the computational tools and concepts used for the integrative interpretation of the rich datasets generated by modern metabolite profiling methods.
Please note that Systems Microbiology does not consider descriptive studies that are solely based on amplicon (e.g., 16S rRNA) profiles, unless they are accompanied by a clear hypothesis and experimentation and provide insight into the microbiological system or process being studied.
Keywords: Microbial Metabolomics, microbe’s metabolism, biosynthetic pathways, human microbiome, computational tools
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