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Erythropoietin and tissue-protective cytokines

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The main focus in cytokine research has been first on their immunomodulating action, then on their role in inflammation. Research has led to the development of successful drugs such as interferons for the therapy of multiple sclerosis and viral infections and anti-TNF molecules for chronic inflammatory ...

The main focus in cytokine research has been first on their immunomodulating action, then on their role in inflammation. Research has led to the development of successful drugs such as interferons for the therapy of multiple sclerosis and viral infections and anti-TNF molecules for chronic inflammatory diseases. Although the interest in erythropoietin (EPO) has originally been in its erythropoietic role and its use in the therapy of anaemia, in the past ten years hundreds of papers have documented the neuro-protective and tissue-protective properties.

Studies have shown that EPO limits damage, prevents inflammation and stimulate repair in various models of tissue injury, and have led to the development of the concept of “tissue-protective cytokines”.

In this research topic we explore various aspects of the emerging role of EPO and other cytokines in tissue protection, including studies on the mechanisms of action, receptors used, pharmacodynamics and safety studies.


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