About this Research Topic
With the advent of new molecular biology tools and new methods for structural analysis, the landscape for discovering and understanding the structures, functions, and biosynthesis of secondary metabolites from extremophiles has changed dramatically during the last decade. As a result, new enzymatic and pharmacological mechanisms of functional metabolites from extremophiles are expected to be revealed.
We welcome high-quality Original Research Articles, Reviews, or Mini-Reviews for this special issue. The topics of this special issue include, but are not limited to:
1. Isolation, structure elucidation, and bioactivity of novel small molecules from extremophiles
2. Characterization of proteins, enzymes and saccharides etc., from the extreme environmental microorganisms.
3. Design, modification, structure-activity relationship study, and pharmacological mechanism of bioactive compounds from extremophiles
4. Genome mining, secondary metabolites and discovery of relevant functional genes and clusters.
Keywords: extremophiles, nature products, pharmacological mechanism, genetic mining, bioactive molecular modification
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.