About this Research Topic

Manuscript Submission Deadline 31 March 2022
Manuscript Extension Submission Deadline 30 April 2022

Extremophiles isolated from deep-sea, hydrothermal vents, cold springs, and polar regions live highly competitive environments. To cope with multiple extreme environmental stresses, they have evolved specific genetic capabilities to produce novel bioactive products, including small molecule secondary ...

Extremophiles isolated from deep-sea, hydrothermal vents, cold springs, and polar regions live highly competitive environments. To cope with multiple extreme environmental stresses, they have evolved specific genetic capabilities to produce novel bioactive products, including small molecule secondary metabolites, proteins, saccharides, etc. The products have important roles in adaptation to species communication, biotechnological, and pharmaceutical applications.

With the advent of new molecular biology tools and new methods for structural analysis, the landscape for discovering and understanding the structures, functions, and biosynthesis of secondary metabolites from extremophiles has changed dramatically during the last decade. As a result, new enzymatic and pharmacological mechanisms of functional metabolites from extremophiles are expected to be revealed.

We welcome high-quality Original Research Articles, Reviews, or Mini-Reviews for this special issue. The topics of this special issue include, but are not limited to:

1. Isolation, structure elucidation, and bioactivity of novel small molecules from extremophiles
2. Characterization of proteins, enzymes and saccharides etc., from the extreme environmental microorganisms.
3. Design, modification, structure-activity relationship study, and pharmacological mechanism of bioactive compounds from extremophiles
4. Genome mining, secondary metabolites and discovery of relevant functional genes and clusters.

Keywords: extremophiles, nature products, pharmacological mechanism, genetic mining, bioactive molecular modification


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