Metastasis is the cause of cancer-related deaths in 90% of the cases. During metastasis, cells change their shape from an epithelial to a mesenchymal morphology exhibiting various migratory protrusions, a process known as epithelial-mesenchymal transition (EMT). EMT involves several cellular changes including dissolution of cell adhesion resulting in dissociation of epithelial cells, induction of the expression of mesenchymal markers and reorganization of actin filaments. Through EMT, cells gain the ability to migrate individually, in a polarized fashion, and invade neighboring tissues to enter the circulatory system. After intravasation, cells survive in the bloodstream as circulating tumor cells (CTCs) and finally, they reach distant organ(s).
We invite researchers to contribute original research and/or review articles that address factors that regulate any of the aforementioned key processes that contribute to the development of cancer.
Potential topics include, but are not limited to, the following factors, processes, and/or mechanisms in targeted therapy in cancer:
- Epithelial-mesenchymal transition (EMT)
- Adhesion molecules and proteases
- Actin-mediated processes in EMT
- Cancer stem cells and EMT
- Molecular targeted therapy in EMT
- EMT and tumor microenvironment
- Novel drugs and/or biomolecules targeting metastasis
- OMICs approaches to address all aspects of metastasis
- Nanomedicine targeting metastatic molecular machinery
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Metastasis is the cause of cancer-related deaths in 90% of the cases. During metastasis, cells change their shape from an epithelial to a mesenchymal morphology exhibiting various migratory protrusions, a process known as epithelial-mesenchymal transition (EMT). EMT involves several cellular changes including dissolution of cell adhesion resulting in dissociation of epithelial cells, induction of the expression of mesenchymal markers and reorganization of actin filaments. Through EMT, cells gain the ability to migrate individually, in a polarized fashion, and invade neighboring tissues to enter the circulatory system. After intravasation, cells survive in the bloodstream as circulating tumor cells (CTCs) and finally, they reach distant organ(s).
We invite researchers to contribute original research and/or review articles that address factors that regulate any of the aforementioned key processes that contribute to the development of cancer.
Potential topics include, but are not limited to, the following factors, processes, and/or mechanisms in targeted therapy in cancer:
- Epithelial-mesenchymal transition (EMT)
- Adhesion molecules and proteases
- Actin-mediated processes in EMT
- Cancer stem cells and EMT
- Molecular targeted therapy in EMT
- EMT and tumor microenvironment
- Novel drugs and/or biomolecules targeting metastasis
- OMICs approaches to address all aspects of metastasis
- Nanomedicine targeting metastatic molecular machinery
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.