About this Research Topic
Neuroblastomas are highly heterogeneous extracranial solid tumors, mostly diagnosed in children under 5 years, and ranging from cases that spontaneously regress to aggressive metastatic tumors with high death rates. In spite of being the most frequent solid tumor in children, a limited number of targeted therapies are currently being used in neuroblastoma treatment.
Anomalous development of sympathetic neuronal cells from their endocrine neural crest precursors prompts the generation of neuroblastoma malignancies. This encourages us to investigate the molecular basis and cell signalling mechanisms governing the physiologic and pathologic developmental biology of neuroendocrine cells. A better understanding of these processes at the molecular, cell, and tissue-development level will help to identify and validate actionable therapeutic molecular targets for the high-risk forms of neuroblastoma with bad prognosis. We are delighted to invite colleagues working in the neuroblastoma field to submit their up-to-date original research, reviews, and perspectives providing novel insights into molecular signalling pathways relevant in neuroblastoma, and how this could impact on the advance of novel neuroblastoma therapies.
The Research Topic is focused on the analysis of cell and developmental signaling processes which, upon a variety of genetic and non-genetic misregulatory mechanisms, drive the initiation and progression of human neuroblastoma.
Specific areas covered by this Research Topic may include, but are not limited to:
- Genetic basis of intracellular signaling in neuroblastoma
- Gene expression regulation and signaling in neuroblastoma
- Molecular regulatory networks in neuroblastoma
- Experimental models for human neuroblastoma
- Molecular basis of neuroblastoma cell differentiation, survival, and growth
- Regulation of receptor and non-receptor kinases and phosphatases in neuroblastoma
- Second messengers in neuroblastoma
- Lipid signaling in neuroblastoma
- Protein post-translational modifications and their impact in neuroblastoma
- Hypoxia and cell signalling in neuroblastoma
- Autophagy and apoptosis pathways in neuroblastoma
- Tumor microenvironment and cell signalling in neuroblastoma
- Regulation of ubiquitination and proteasomal protein degradation in neuroblastoma
- Small molecule targeted drugs and their application in neuroblastoma
- Targeted immunotherapy in neuroblastoma
- Chemoresistance in neuroblastoma
Keywords: neuroblastoma, cellular signaling, chemoresistance, gene expression, gene regulation, intracellular signaling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.