About this Research Topic
Injury to the gastrointestinal tract is a major contributor to acute and chronic gut diseases. Gastro-intestinal injury of varied etiology may progress to Acute Gastrointestinal Failure and/or gastrointestinal carcinoma. Compromised microbiota is thought to be a deciding factor of cellular hypoxia and may be involved in disease progression. Thus, it needs early detection. Chronic alcohol consumption also produces changes in gut flora and direct toxic injury.
This Research Topic has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in microbiology, providing an online forum for rapid dissemination of recent research and perspectives in this area.
Articles will span across the discipline and will include challenges of treating bacterial infections in elderly patients with inflammatory bowel disease (IBD), novel interventions to reduce healthcare-associated infections, innovations in using cytokines and chemokines as biomarkers for surveillance of inflammation and repair, the present and future state of gut microbiota and predictors for IBD outcome, and the potential of metagenomic sequencing as a first-line diagnostic tool.
The collection will incorporate new innovative articles on molecular aspects of intestinal metabolomics providing an opportunity for leading experts in the field of clinical microbiology and infectious diseases to engage with early-career researchers and academics.
This Research Topic is dedicated to publishing Original Research, including basic laboratory research and animal studies. Review articles include expert opinion/perspective reviews (including microbiological characterization and drug/therapeutic interventions). We welcome contributions presenting the latest knowledge on the experimental models, translational and clinical data-specific syndromes.
The discovery of non-invasive diagnostic biomarkers to identify patients with IBD and inflammatory bowel syndrome (IBS) who are prone to progress to malignancy is a task for the clinicians and laboratory medicine as well. Scientists must work in concert to identify methods of surveillance for populations at risk. In this collection, we will update basic scientists and clinicians on the latest occurrences of this syndrome.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.