About this Research Topic
The Research Topic will focus on this new technique as a tool to deliver genetic information coding for protective AMP peptides in situ into MDR- pathogen-attacked host cells.
Synthetic mRNAs can be engineered to transiently express peptides by structurally resembling natural mRNA, providing an option for controlling the translational efficacy and reducing immunogenicity of the (IVT)mRNA. Advances in addressing the inherent challenges of this novel drug class, particularly related to controlling the translational efficacy and immunogenicity of the IVTmRNA, provide a basis for a broad range of potential applications. So far it has been used mainly in vaccine production. Multiple mRNA vaccine platforms have been developed and evaluated in small and large animals and humans successfully, but not for AMP application as of yet. The success of mRNA-lipid nanoparticle vaccines against single-stranded, positive (+) sense RNA beta coronavirus COVID-19 indicates an encouraging perspective of biological therapeutics, including a renaissance of the antimicrobial peptide-based battle against multidrug-resistant bacterial, oomycete, and fungal pathogens both in animals and perhaps in plants. The Research Topic intends to open a platform for pioneering publication in this research field.
The present Research Topic aims at gathering relevant articles (such as original research papers, perspectives, and full and mini-review articles) opening a new chapter in the battle with MDR with the tool of AMPs optimized at mRNA level and delivered as ITVmRNA. The specific topics of the research topic are including, but not limited to:
· Antimicrobial Peptides and Antimicrobial Nucleic Acids as Antibacterial and Antiviral Agents;
· Antimicrobial peptide, and mRNA;
· mRNA therapy
· In vitro transcribed and optimized RNA-based therapeutics;
· Experiments on autoimmune mutants in model model-organisms;
· Genetics and immunity;
· Structure identification, bioinformatics, quantitative structure analysis (QASR) optimization of single-gene encoded ribosomal templated AMPs;
· Discovery, structure identification non-ribosomal templated (NRP) amps, revealing the genetic organization and regulation of the respective biosynthetic gene complexes;
· Plant immunity
Keywords: Multidrug-resistance (MDR), Antimicrobial Peptides (AMPs), mRNA-Therapy, mRNA administration, mRNA immunogenicity, Innate immunity, Plant immunity, (Auto)immune experimental models
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.