About this Research Topic
1. lncRNAs being a central component in the epigenetic control of gene expression
2. Given the ability of RNA to act as a ‘molecular glue’ and the fact that most transcribed RNAs are non-coding, lncRNAs can be critical for the generation, integrity, and function of subcellular “phase-separated” condensates
3. Given that lncRNAs are mostly nuclear, rich in repeat elements, and able to interact with DNA, RNA, and proteins, they also play a role in genome organization both locally and globally
As the field is leaving its infancy, with this Research Topic, we aim at summarizing the current state of the art and discussing emerging directions as a collection of focused reviews, as well as original research and theory articles. Provocative yet constructive opinion pieces on lncRNA biology are also welcome.
Given the breadth of the field, this Research Topic will focus on addressing the following:
• lncRNAs as epigenetic controllers of gene expression in development, homeostasis, and disease.
• lncRNAs in phase separation, formation, and function of subcellular condensates, including nuclear condensates and stress granules.
• lncRNAs in 3D genome organization and gene regulation.
• Functional genomics and biochemical approaches to comprehensively dissect lncRNAs.
• Emerging technologies, including systems biology tools, to address RNA-DNA and RNA-protein interactions, RNA secondary and tertiary structures, RNA-dependent DNA conformation changes, RNA-dependent protein subcellular localization.
Keywords: lncRNAs, epigenetics, gene expression, nuclear condensates, stress granules, 3D genome organization, development, homeostasis, disease, systems biology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.