Diabetes is a global health problem caused by the inability of pancreatic ß-cells to secrete adequate levels of insulin. Although ß-cell failure is a key pathomechanism in both type 1 and type 2 diabetes, its causes are far from being fully elucidated. The hormone-secreting islet cells and the insulin/glucagon sensing cells in liver, muscles, and adipose tissues, are functionally disturbed in diabetes. Besides that, activation of the immune system impairs insulin secretion and its action in both type1 and type 2 diabetes. There are complex changes in metabolic pathways in these cells, which affect their functions, before and after the onset of diabetes. More research is therefore needed to understand the pathological roles and improve the prediction, early diagnosis, and treatment of diabetes.
This Research Topic aims to explore the endocrine and immune cells abnormalities in the development of diabetes, illustrate or comment on the mechanisms underlying the pathogenesis of diabetes with a focus on the metabolic phenotypes and the resulting dysfunction of cells. Moreover, crosstalk between endocrine and immune cells is also taken into consideration.
Topics of interest include, but are not limited to:
• Metabolic disturbance and cellular function in endocrine and immune cells in diabetes
• Interaction between endocrine and immune cells in function and metabolism
• Immunological and metabolic biomarkers for the prediction, staging,diagnosis and monitor of diabetes
• Immunological and metabolic intervention and treatment options in diabetes and future direction
Diabetes is a global health problem caused by the inability of pancreatic ß-cells to secrete adequate levels of insulin. Although ß-cell failure is a key pathomechanism in both type 1 and type 2 diabetes, its causes are far from being fully elucidated. The hormone-secreting islet cells and the insulin/glucagon sensing cells in liver, muscles, and adipose tissues, are functionally disturbed in diabetes. Besides that, activation of the immune system impairs insulin secretion and its action in both type1 and type 2 diabetes. There are complex changes in metabolic pathways in these cells, which affect their functions, before and after the onset of diabetes. More research is therefore needed to understand the pathological roles and improve the prediction, early diagnosis, and treatment of diabetes.
This Research Topic aims to explore the endocrine and immune cells abnormalities in the development of diabetes, illustrate or comment on the mechanisms underlying the pathogenesis of diabetes with a focus on the metabolic phenotypes and the resulting dysfunction of cells. Moreover, crosstalk between endocrine and immune cells is also taken into consideration.
Topics of interest include, but are not limited to:
• Metabolic disturbance and cellular function in endocrine and immune cells in diabetes
• Interaction between endocrine and immune cells in function and metabolism
• Immunological and metabolic biomarkers for the prediction, staging,diagnosis and monitor of diabetes
• Immunological and metabolic intervention and treatment options in diabetes and future direction
