About this Research Topic
A cardinal feature of adaptive immunity is its ability to generate memory T cells. Although they are essential to protection against infections, especially in the face of immunosuppression after transplantation, memory T cells mediate vigorous allograft rejection and are a barrier to transplant tolerance. Both antigen-experienced and homeostatically proliferated T cells can give rise to memory cells while preexisting memory T cells also pose a threat to transplant survival. Memory T cells exhibit a feature of heterogeneity with differential phenotypes and functionality, such as central versus effector memory and "exhausted" memory cells. It's known that CD4+CD25+ Tregs have a memory phenotype of CD44highCD62L+. Recent studies also have shown that CD8+ T cells with memory phenotypes (CD122+) contain both effector and regulator components. Thus, memory T cells play dual roles in transplant survival or tolerance. This Research Topic will provide a comprehensive overview of various components of memory effectors, exhausted memory and memory-like regulatory T cells. In this topic, we will explore possible cellular and molecular pathways involved in memory T cell-mediated rejection or survival and discuss new strategies of inducing transplant tolerance while preserving immunity to pathogens.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.