People are suffering more and more from chronic diseases. Many chronic diseases increasingly affect the human immune status, which might cause people immunodeficient. Patients considered immunodeficient include organ or stem cell transplant patients, people with AIDS, people on immunosuppressive drugs, and other autoimmune diseases. People with immune abnormalities increase the probability of opportunistic microbial infections, but different types of immunodeficient people have different opportunities for infection. For example, conditional pathogenic bacteria such as Pneumocystis jirovecii and Penicillium Marneffei have been detected in patient samples, which usually do not need to be considered as pathogenic for immunocompetent people, while they are likely to be pathogenic for some immunodeficient patients. Therefore, it is necessary to estimate the full immune status of the patient when considering the pathogens of infectious diseases.
In recent years, with the help of metagenomic sequencing(mNGS), which allows unbiased detection of thousands of pathogens without hypothetical pathogens, effectively detected pathogens in critical cases. The technique also provides the genomic or genetic information of the host, which is usually discarded, that can be used for host immunity studies. Thus, it’s allowing a more comprehensive assessment of the pathogenic characteristics of immunodeficient patients by considering both pathogens and immunity.
This Research Topic aims to discuss how to perform simultaneous pathogen and immune evaluation by clinical samples, how to explore the differences in response to different pathogens in different immunodeficiency types, and to provide guidance for clinical targeting of drugs and precision therapy strategies.
We welcome Reviews, Mini-Reviews, Perspectives, Brief Research Reports, and Original Research Articles focusing on the following themes:
• Original method development for distinguishing microbes as colonization and infection in clinical samples.
• Evaluation of risk levels/cutoff for infection by fungi in immunocompromised conditions.
• Investigation of pathogen-specific immune response for a different kind of pathogen.
• Quickly immune monitoring methods for the disease treatment process.
• Early warning for immune rejection/infection in transplant patients.
People are suffering more and more from chronic diseases. Many chronic diseases increasingly affect the human immune status, which might cause people immunodeficient. Patients considered immunodeficient include organ or stem cell transplant patients, people with AIDS, people on immunosuppressive drugs, and other autoimmune diseases. People with immune abnormalities increase the probability of opportunistic microbial infections, but different types of immunodeficient people have different opportunities for infection. For example, conditional pathogenic bacteria such as Pneumocystis jirovecii and Penicillium Marneffei have been detected in patient samples, which usually do not need to be considered as pathogenic for immunocompetent people, while they are likely to be pathogenic for some immunodeficient patients. Therefore, it is necessary to estimate the full immune status of the patient when considering the pathogens of infectious diseases.
In recent years, with the help of metagenomic sequencing(mNGS), which allows unbiased detection of thousands of pathogens without hypothetical pathogens, effectively detected pathogens in critical cases. The technique also provides the genomic or genetic information of the host, which is usually discarded, that can be used for host immunity studies. Thus, it’s allowing a more comprehensive assessment of the pathogenic characteristics of immunodeficient patients by considering both pathogens and immunity.
This Research Topic aims to discuss how to perform simultaneous pathogen and immune evaluation by clinical samples, how to explore the differences in response to different pathogens in different immunodeficiency types, and to provide guidance for clinical targeting of drugs and precision therapy strategies.
We welcome Reviews, Mini-Reviews, Perspectives, Brief Research Reports, and Original Research Articles focusing on the following themes:
• Original method development for distinguishing microbes as colonization and infection in clinical samples.
• Evaluation of risk levels/cutoff for infection by fungi in immunocompromised conditions.
• Investigation of pathogen-specific immune response for a different kind of pathogen.
• Quickly immune monitoring methods for the disease treatment process.
• Early warning for immune rejection/infection in transplant patients.
